Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, Scheiner O, Breitenbach M: The gene coding for the major birch pollen allergen BetvI, is highly homologous to a pea disease resistance response gene. EMBO Journal. 1989, 8: 1935-1938.
PubMed
PubMed Central
Google Scholar
Jarolim E, Rumpold H, Endler AT, Ebner H, Breitenbach M, Scheiner O, Kraft D: IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa. Allergy. 1989, 44: 385-395. 10.1111/j.1398-9995.1989.tb04169.x.
Article
PubMed
Google Scholar
Niederberger V, Pauli G, Gronlund H, Froschl R, Rumpold H, Kraft D, Valenta R, Spitzauer S: Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: A quantitative IgE inhibition study with sera from different populations. J Allergy Clin Immunol . 1998, 102 (4 Pt 1): 579-91. 10.1016/S0091-6749(98)70273-8.
Article
PubMed
Google Scholar
Bollen MA, Aranzazu G, Cordewener JHG, Wichers HJ, Helsper JPFG, Savelkoul HFJ, Van Boekel MAJS: Purification and characterization of natural Bet v 1 from birch pollen and related allergens from carrot and celery. Mol Nutr Food Res. 2007, 51 (12): 1527-36. 10.1002/mnfr.200700119.
Article
PubMed
Google Scholar
Fritsch R, Bohle B, Vollmann U, Wiedermann U, Jahn-Schmid B, Krebitz M, Breiteneder H, Kraft D, Ebner C: Bet v 1, the major birch pollen allergen, and Mal d 1, the major apple allergen, cross-react at the level of allergen-specific T helper cells. J Allergy Clin Immunol. 1998, 102 (4 Pt 1): 679-86. 10.1016/S0091-6749(98)70287-8.
Article
PubMed
Google Scholar
Karlsson AL, Alm R, Ekstrand B, Fjelkner-Modig S, Schiött A, Bengtsson U, Björk L, Hjernø K, Roepstorff P, Emanuelsson CS: Bet v 1 homologues in strawberry identified as IgE-binding proteins and presumptive allergens. Allergy. 2004, 59: 1277-1284. 10.1111/j.1398-9995.2004.00585.x.
Article
PubMed
Google Scholar
Scheurer S, Son DY, Boehm M, Karamloo F, Franke S, Hoffmann A, Haustein D, Vieths S: Cross-reactivity and epitope analysis of Pru a 1, the major cherry allergen. Molecular Immunology. 1999, 36: 155-167. 10.1016/S0161-5890(99)00033-4.
Article
PubMed
Google Scholar
Bohle B, Radakovics A, Jahn-Schmid B, Hoffmann-Sommergruber K, Fischer GF, Ebner C: Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level. European Journal of Immunology. 2003, 33: 3303-3310. 10.1002/eji.200324321.
Article
PubMed
Google Scholar
Ferreira F, Hawranek T, Gruber P, Wopfner N, Mari A: Allergic cross-reactivity: from gene to the clinic. Allergy. 2004, 59: 243-267. 10.1046/j.1398-9995.2003.00407.x.
Article
PubMed
Google Scholar
Breiteneder H, Ebner C: Molecular and biochemical classification of plant-derived food allergens. J Allergy Clin Immunol. 2000, 106 (1 Pt 1): 27-36. 10.1067/mai.2000.106929.
Article
PubMed
Google Scholar
De Jong PC: An introduction to betula: Its morphology, evolution, classification and distribution with a survey of recent work. The IDS Betula Symposium, International Dendrology Soc: 1993; Sussex, U.K. 1993.
Google Scholar
Järvinen P, Palmé A, Morales LO, Lännenpää M, Keinänen M, Sopanen T, Lascoux M: Phylogenetic relationships of Betula species (Betulaceae) based on nuclear ADH and chloroplast matK sequences. American Journal of Botany. 2004, 91: 1834-1845. 10.3732/ajb.91.11.1834.
Article
PubMed
Google Scholar
Schenk MF, Thienpont C-N, Koopman WJM, Gilissen LJWJ, Smulders MJM: Phylogenetic relationships in Betula (Betulaceae) based on AFLP markers. 911-924. 4. ISSN 1614-2942
Eriksson NE, Holmén A, Möller C, Wihl JÅ: Sensitization according to skin prick testings in atopic patients with asthma or rhinitis at 24 allergy clinica in Northern Europe and Asia. Allergology International. 1998, 47: 187-196. 10.2332/allergolint.47.187.
Article
Google Scholar
Abe Y, Kimura S, Kokubo T, Mizumoto K, Uehara M, Katagiri M: Epitope analysis of birch pollen allergen in Japanese subjects. Journal of Clinical Immunology. 1997, 17: 485-493. 10.1023/A:1027323811296.
Article
PubMed
Google Scholar
Bolhaar STHP, Weg Van de WE, Van Ree R, Gonzalez-Macebo E, Zuidmeer L, Bruijnzeel-Koomen CAFM, Fernandez-Rivas M, Jansen J, Hoffmann-Sommergruber K, Knulst AC, et al: In vivo assessment with prick-to-prick testing and double-blind, placebo-controlled food challenge of allergenicity of apple cultivars. J Allergy Clin Immunol. 2005, 116 (5): 1080-6. 10.1016/j.jaci.2005.07.004.
Article
PubMed
Google Scholar
Marzban G, Puehringer H, Dey R, Brynda S, Ma Y, Martinelli A, Zaccarini M, Weg van der E, Housley Z, Kolarich D, et al: Localisation and distribution of the major allergens in apple fruits. Plant Science. 2005, 169: 387-394. 10.1016/j.plantsci.2005.03.027.
Article
Google Scholar
Gao Z, Weg Van de EW, Matos CI, Arens P, Bolhaar STHP, Knulst AC, Li Y, Hoffmann-Sommergruber K, Gilissen LJWJ: Assessment of allelic diversity in intron-containing Mal d 1 genes and their association to apple allergenicity. BMC Plant Biol. 2008, 8: 116-10.1186/1471-2229-8-116.
Article
PubMed
PubMed Central
Google Scholar
Ahrazem O, Jimeno L, López-Torrejón G, Herrero M, Espada JL, Sánchez-Monge R, Duffort O, Barber D, Salcedo G: Assessing allergen levels in peach and nectarine cultivars. Ann Allergy Asthma Immunol. 2007, 99 (1): 42-7.
Article
PubMed
Google Scholar
Castro AJ, Alche JD, Cuevas J, Romero PJ, Alche V, Rodriguez-Garcia MI: Pollen from different olive tree cultivars contains varying amounts of the major allerge n ole e 1. International Archives of Allergy and Immunology. 2003, 131: 164-173. 10.1159/000071482.
Article
PubMed
Google Scholar
Ekramoddoullah AKM, Yu XS, Sturrock R, Zamani A, Taylor D: Detection and seasonal expression pattern of a pathogenesis-related protein (PR-10) in Douglas-fir (Pseudotsuga menziesii) tissues. Physiologia Plantarum. 2000, 110: 240-247. 10.1034/j.1399-3054.2000.110214.x.
Article
Google Scholar
Gao ZS, Weg van de WE, Schaart JG, Schouten HJ, Tran DH, Kodde LP, Meer van der IM, Geest van der AHM, Kodde J, Breiteneder H, et al: Genomic cloning and linkage mapping of the Mal d 1 (PR-10) gene family in apple (Malus domestica). Theoretical And Applied Genetics. 2005, 111: 171-183. 10.1007/s00122-005-2018-4.
Article
PubMed
Google Scholar
Huang JC, Chang FC, Wang CS: Characterization of a lily tapetal transcript that shares sequence similarity with a class of intracellular pathogenesis-related (IPR) proteins. Plant Molecular Biology. 1997, 34: 681-686. 10.1023/A:1005824306560.
Article
PubMed
Google Scholar
Van Loon LC, Van Strien EA: The families of pathogenesis-related proteins, their activities, and comparative analysis of PR-1 type proteins. Physiological and Molecular Plant Pathology. 1999, 55: 85-97. 10.1006/pmpp.1999.0213.
Article
Google Scholar
Pühringer H, Moll D, Hoffmann-Sommergruber K, Watillon B, Katinger H, Machado MLD: The promoter of an apple Ypr10 gene, encoding the major allergen Mal d 1, is stress- and pathogen-inducible. Plant Science. 2000, 152: 35-50. 10.1016/S0168-9452(99)00222-8.
Article
Google Scholar
Robert N, Ferran J, Breda C, Coutos-Thevenot P, Boulay M, Buffard D, Esnault R: Molecular characterization of the incompatible interaction of Vitis vinifera leaves with Pseudomonas syringae pv. pisi: Expression of genes coding for stilbene synthase and class 10 PR protein. European Journal of Plant Pathology. 2001, 107: 249-261. 10.1023/A:1011241001383.
Article
Google Scholar
Swoboda I, Scheiner O, Heberle-Bors E, Vicente O: cDNA cloning and characterization of three genes in the Bet v 1 gene family that encode pathogenesis-related proteins. Plant Cell and Environment. 1995, 18: 865-874. 10.1111/j.1365-3040.1995.tb00595.x.
Article
Google Scholar
Poupard P, Strullu DG, Simoneau P: Two members of the Bet v 1 gene family encoding birch pathogenesis-related proteins display different patterns of root expression and wound-inducibility. Australian Journal of Plant Physiology. 1998, 25: 459-464.
Article
Google Scholar
Moons A, Prinsen E, Bauw G, Van Montagu M: Antagonistic effects of abscisic acid and jasmonates on salt stress-inducible transcripts in rice roots. Plant Cell. 1997, 9: 2243-2259. 10.1105/tpc.9.12.2243.
Article
PubMed
PubMed Central
Google Scholar
Utriainen M, Kokko H, Auriola S, Sarrazin O, Karenlampi S: PR-10 protein is induced by copper stress in roots and leaves of a Cu/Zn tolerant clone of birch, Betula pendula. Plant Cell and Environment. 1998, 21: 821-828. 10.1046/j.1365-3040.1998.00326.x.
Article
Google Scholar
Walter MH, Liu JW, Wünn J, Hess D: Bean ribonuclease-like pathogenesis-related protein genes (Ypr10) display complex patterns of developmental, dark-induced and exogenous-stimulus-dependent expression. European Journal of Biochemistry. 1996, 239: 281-293. 10.1111/j.1432-1033.1996.0281u.x.
Article
PubMed
Google Scholar
Schenk MF, Gilissen LJWJ, Esselink GD, Smulders MJM: Seven different genes encode a diverse mixture of isoforms of Bet v I, the major birch pollen allergen. BMC Genomics. 2006, 7: 168-10.1186/1471-2164-7-168.
Article
PubMed
PubMed Central
Google Scholar
Friedl-Hajek R, Radauer C, O'Riordain G, Hoffmann-Sommergruber K, Leberl K, Scheiner O, Breiteneder H: New Bet v 1 isoforms including a naturally occurring truncated form of the protein derived from Austrian birch pollen. Molecular Immunology. 1999, 36: 639-645. 10.1016/S0161-5890(99)00078-4.
Article
PubMed
Google Scholar
Swoboda I, Jilek A, Ferreira F, Engel E, Hoffmann-Sommergruber K, Scheiner O, Kraft D, Breiteneder H, Pittenauer E, Schmid E, et al: Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid-chromatography, mass-spectrometry, and cDNA cloning. Journal of Biological Chemistry. 1995, 270: 2607-2613. 10.1074/jbc.270.6.2607.
Article
PubMed
Google Scholar
Wen J, Vanek-Krebitz M, Hoffmann-Sommergruber K, Scheiner O, Breiteneder H: The potential of Betv1 homologues, a nuclear multigene family, as phylogenetic markers in flowering plants. Mol Phylogenet Evol. 1997 Dec;8(3):317-33. 1997, 8 (3): 317-33. 10.1006/mpev.1997.0447.
Google Scholar
Hoffmann-Sommergruber K, Vanek-Krebitz M, Radauer C, Wen J, Ferreira F, Scheiner O, Breiteneder H: Genomic characterization of members of the Bet v 1 family: genes coding for allergens and pathogenesis-related proteins share intron positions. Gene. 1997, 197: 91-100. 10.1016/S0378-1119(97)00246-1.
Article
PubMed
Google Scholar
Ferreira F, Hirtenlehner K, Jilek A, Godnik-Cvar J, Breiteneder H, Grimm R, Hoffmann-Sommergruber K, Scheiner O, Kraft D, Breitenbach M, et al: Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: Potential use of hypoallergenic isoforms for immunotherapy. Journal of Experimental Medicine. 1996, 183: 599-609. 10.1084/jem.183.2.599.
Article
PubMed
Google Scholar
Helsper J, Gilissen L, van Ree R, America AHP, Cordewener JHG, Bosch D: Quadrupole time-of-flight mass spectrometry: A method to study the actual expression of allergen isoforms identified by PCR cloning. J Allergy Clin Immunol. 2002, 110 (1): 131-8. 10.1067/mai.2002.125599.
Article
PubMed
Google Scholar
Silva JC, Denny R, Dorschel CA, Gorenstein M, Kass IJ, Li GZ, McKenna T, Nold MJ, Richardson K, Young P, et al: Quantitative proteomic analysis by accurate mass retention time pairs. Analytical Chemistry. 2005, 77: 2187-2200. 10.1021/ac048455k.
Article
PubMed
Google Scholar
Liao DQ: Concerted evolution: Molecular mechanism and biological implications. American Journal of Human Genetics. 1999, 64: 24-30. 10.1086/302221.
Article
PubMed
PubMed Central
Google Scholar
Ohta T: Evolution of gene families. Gene. 2000, 259: 45-52. 10.1016/S0378-1119(00)00428-5.
Article
PubMed
Google Scholar
Nei M, Rooney AP: Concerted and birth-and-death evolution of multigene families. Annual Review of Genetics. 2005, 39: 121-152. 10.1146/annurev.genet.39.073003.112240.
Article
PubMed
PubMed Central
Google Scholar
Poupard P, Brunel N, Leduc N, Viémont JD, Strullu D-G, Simoneau P: Expression of a Bet v 1 homologue gene encoding a PR 10 protein in birch roots: induction by auxin and localization of the transcripts by in situ hybridization. Australian Journal of Plant Physiology. 2001, 28: 57-63.
Google Scholar
Valjakka M, Luomala EM, Kangasjärvi J, Vapaavuori E: Expression of photosynthesis- and senescence-related genes during leaf development and senescence in silver birch (Betula pendula) seedlings. Physiologia Plantarum. 1999, 106: 302-310. 10.1034/j.1399-3054.1999.106307.x.
Article
Google Scholar
Swoboda I, Dang TCH, Heberle-Bors E, Vicente O: Expression of Bet v 1, the major birch pollen allergen, during anther development – An in situ hybridization study. Protoplasma. 1995, 187: 103-110. 10.1007/BF01280237.
Article
Google Scholar
Larsen JN: Isoallergens – significance in allergen exposure and response. ACI News. 1995, 7: 141-160.
Google Scholar
Chassaigne H, Nørgaard JV, Van Hengel AJ: Proteomics-based approach to detect and identify major allergens in processed peanuts by capillary LC-Q-TOF (MS/MS). J Agric Food Chem. 2007, 55 (11): 4461-73. 10.1021/jf063630e.
Article
PubMed
Google Scholar
Napoli A, Aiello D, Di Donna L, Moschidis P, Sindona G: Vegetable proteomics: the detection of Ole e 1 isoallergens by peptide matching of MALDI MS/MS spectra of underivatized and dansylated glycopeptides. Journal of proteome research. 2008, 7 (7): 2723-2732. 10.1021/pr700855u.
Article
PubMed
Google Scholar
Ferreira F, Hirthenlehner K, Briza P, Breiteneder H, Scheiner O, Kraft D, Breitenbach M, Ebner C: Isoforms of atopic allergens with reduced allergenicity but conserved T cell antigenicity: Possible use for specific immunotherapy. Int Arch Allergy Immunol. 1997, 113 (1-3): 125-7.
Article
PubMed
Google Scholar
Wagner S, Radauer C, Bublin M, Hoffmann-Sommergruber K, Kopp T, Greisenegger EK, Vogel L, Vieths S, Scheiner O, Breiteneder H: Naturally occurring hypoallergenic Bet v 1 isoforms fail to induce IgE responses in individuals with birch pollen allergy. J Allergy Clin Immunol. 2008, 121 (1): 246-52. 10.1016/j.jaci.2007.08.006.
Article
PubMed
Google Scholar
Markovic-Housley Z, Degano M, Lamba D, von Roepenack-Lahaye E, Clemens S, Susani M, Ferreira F, Scheiner O, Breiteneder H: Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. Journal of Molecular Biology. 2003, 325: 123-133. 10.1016/S0022-2836(02)01197-X.
Article
PubMed
Google Scholar
Ferreira F, Ebner C, Kramer B, Casari G, Briza P, Kungl AJ, Grimm R, Jahn-Schmid B, Breiteneder H, Kraft D, et al: Modulation of IgE reactivity of allergens by site-directed mutagenesis: potential use of hypoallergenic variants for immunotherapy. Faseb Journal. 1998, 12: 231-242.
PubMed
Google Scholar
Son DY, Scheurer S, Hoffmann A, Haustein D, Vieths S: Pollen-related food allergy: cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen, and Bet v 1, the major birch pollen allergen. European Journal of Nutrition. 1999, 38: 201-215. 10.1007/s003940050063.
Article
PubMed
Google Scholar
Neudecker P, Lehmann K, Nerkamp J, Haase T, Wangorsch A, Fötisch K, Hoffmann S, Rösch P, Vieths S, Scheurer S: Mutational epitope analysis of Pru av 1 and Api g 1, the major allergens of cherry (Prunus avium) and celery (Apium graveolens): correlating IgE reactivity with three-dimensional structure. Biochemical Journal. 2003, 376: 97-107. 10.1042/BJ20031057.
Article
PubMed
PubMed Central
Google Scholar
Swofford DL: PAUP*. Phylogenetic Analysis Using Parsimony (*and Other Methods). Version 4. Sinauer Associates, Sunderland, Massachusetts; 2003.
Google Scholar
Rozas J, Sanchez-DelBarrio JC, Messeguer X, Rozas R: DnaSP, DNA polymorphism analyses by the coalescent and other methods. Bioinformatics. 2003, 19: 2496-2497. 10.1093/bioinformatics/btg359.
Article
PubMed
Google Scholar
Cadot P, Lejoly M, Vanhoeyveld EW, Stevens EAM: Influence of the pH of the extraction medium on the composition of birch (Betula verrucosa) pollen extracts. Allergy. 1995, 50 (5): 431-437. 10.1111/j.1398-9995.1995.tb01173.x.
Article
PubMed
Google Scholar
Shevchenko A, Wilm M, Vorm O, Mann M: Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels. Analytical Chemistry. 1996, 68: 850-858. 10.1021/ac950914h.
Article
PubMed
Google Scholar
De Groot JCW, Fiers MWEJ, Van Ham RCHJ, America AHP: Post alignment clustering procedure for comparative quantitative proteomics LC-MS Data. Proteomics. 2008, 8: 32-36. 10.1002/pmic.200700707.
Article
PubMed
Google Scholar