Tripoli E, La Guardia M, Giammanco S, Di Majo D, Giammanco M. Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review. Food Chem. 2007;104:466–79.
Article
CAS
Google Scholar
Huang D, Wang X, Tang Z, Yuan Y, Xu Y, He J, et al. Subfunctionalization of the Ruby2–Ruby1 gene cluster during the domestication of citrus. Nat Plants. 2018;4:930–41. https://doi.org/10.1038/s41477-018-0287-6.
Article
CAS
PubMed
Google Scholar
Andersen OM, Markham KR. Flavonoids: chemistry, biochemistry and applications. Boca Raton: Taylor & Francis: CRC Press; 2005.
Book
Google Scholar
Kaur H, Heinzel N, Schöttner M, Baldwin IT, Gális I. R2R3-NaMYB8 regulates the accumulation of phenylpropanoid-polyamine conjugates, which are essential for local and systemic defense against insect herbivores in Nicotiana attenuata. Plant Physiol. 2010;152:1731–47.
Article
CAS
PubMed
PubMed Central
Google Scholar
Luo J, Butelli E, Jones J, Tomlinson L, Martin CR. Methods and compositions for modifying plant flavonoid composition and disease resistance. 2009; http://europepmc.org/patents/PAT/WO2009103960. Accessed 27 Aug 2009.
Google Scholar
Butelli E, Titta L, Giorgio M, Mock H-P, Matros A, Peterek S, et al. Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nat Biotechnol. 2008;26:1301–8.
Article
CAS
PubMed
Google Scholar
Liu Y, Heying E, Tanumihardjo SA. History, global distribution, and nutritional importance of citrus fruits. Compr Rev Food Sci Food Saf. 2012;11:530–45.
Article
CAS
Google Scholar
Santos-buelga C, Scalbert A. Review proanthocyanidins and tannin-like compounds – nature, occurrence, dietary intake and effects on nutrition and health. J Sci Food Agric. 2000;80:1094–117.
Dixon R, Xie D, Sharma S. Proanthocyanidins a final frontier in flavonoid research? New Phytol. 2005;165:9–28.
Article
CAS
PubMed
Google Scholar
Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond 1–3. Am J Clin Nutr. 2005;81:215–7.
Article
Google Scholar
Amorini AM, Lazzarino G, Galvano F, Fazzina G, Tavazzi B, Galvano G. Cyanidin-3-O-β-glucopyranoside protects myocardium and erythrocytes from oxygen radical-mediated damages. Free Radic Res. 2003;37:453–60.
Article
CAS
PubMed
Google Scholar
Winkel-Shirley B. Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. Plant Physiol. 2001;126:485–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Martinelli F, Reagan RL, Uratsu SL, Phu ML, Albrecht U, Zhao W, et al. Gene regulatory networks elucidating huanglongbing disease mechanisms. PLoS ONE. 2013;8:e74256.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu M, Li Y, Zheng Z, Dai Z, Tao Y, Deng X. Transcriptional analyses of mandarins seriously infected by ‘Candidatus Liberibacter asiaticus’. PLoS One. 2015;10:e0133652.
Article
PubMed
PubMed Central
CAS
Google Scholar
Wang Y, Zhou L, Yu X, Stover E, Luo F, Duan Y. Transcriptome profiling of Huanglongbing (HLB) tolerant and susceptible citrus plants reveals the role of basal resistance in HLB tolerance. Front Plant Sci. 2016;7:933.
PubMed
PubMed Central
Google Scholar
Aritua V, Achor D, Gmitter FG, Albrigo G, Wang N. Transcriptional and microscopic analyses of citrus stem and root responses to Candidatus Liberibacter asiaticus infection. PLoS One. 2013;8:e73742.
Article
CAS
PubMed
PubMed Central
Google Scholar
Agati G, Tattini M. Multiple functional roles of flavonoids in photoprotection. New Phytol. 2010;186:786–93.
Article
CAS
PubMed
Google Scholar
Kolb CA, Käser MA, Kopecký J, Zotz G, Riederer M, Pfündel EE. Effects of natural intensities of visible and ultraviolet radiation on epidermal ultraviolet screening and photosynthesis in grape leaves. Plant Physiol. 2001;127:863–75.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rao MJ, Ding F, Wang N, Deng X, Xu Q. Metabolic mechanisms of host species against citrus Huanglongbing (Greening Disease). Crit Rev Plant Sci. 2019;0:1–16.
Google Scholar
Mafra V, Kubo KS, Alves-Ferreira M, Ribeiro-Alves M, Stuart RM, Boava LP, et al. Reference genes for accurate transcript normalization in citrus genotypes under different experimental conditions. PLoS One. 2012;7:e31263.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fan J, Chen C, Yu Q, Khalaf A, Achor DS, Brlansky RH, et al. Comparative transcriptional and anatomical analyses of tolerant rough lemon and susceptible sweet orange in response to ‘Candidatus Liberibacter asiaticus’ infection. Mol Plant-Microbe Interact. 2012;25:1396–407.
Article
CAS
PubMed
Google Scholar
Chhikara N, Kour R, Jaglan S, Gupta P, Gat Y, Panghal A. Citrus medica: nutritional, phytochemical composition and health benefits–a review. Food Funct. 2018;9:1978–92.
Article
CAS
PubMed
Google Scholar
Agati G, Stefano G, Biricolti S, Tattini M. Mesophyll distribution of ‘antioxidant’flavonoid glycosides in Ligustrum vulgare leaves under contrasting sunlight irradiance. Ann Bot. 2009;104:853–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tanaka T. Fundamental discussion of citrus classification. Stud Citrol. 1977;14:1–6.
Google Scholar
Li Y, Baldauf S, Lim EK, Bowles DJ. Phylogenetic analysis of the UDP-glycosyltransferase multigene family of Arabidopsis thaliana. J Biol Chem. 2001;276:4338–43.
Article
CAS
PubMed
Google Scholar
Douglas Grubb C, Zipp BJ, Ludwig-Müller J, Masuno MN, Molinski TF, Abel S. Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis. Plant J. 2004;40:893–908.
Article
PubMed
CAS
Google Scholar
Offen W, Martinez-fleites C, Yang M, Kiat-lim E, Davis BG, Tarling CA, et al. Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification. EMBO J. 2006;25:1396–405.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li J, Liu X, Gao Y, Zong G, Wang D, Liu M, et al. Phytochemistry identification of a UDP-Glucosyltransferase favouring substrate- and regio- specific biosynthesis of flavonoid glucosides in Cyclocarya paliurus. Phytochemistry. 2019;163:75–88.
Article
CAS
PubMed
Google Scholar
Tohge T, Nishiyama Y, Hirai MY, Yano M, Nakajima J, Awazuhara M, et al. Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor. Plant J. 2005;42:218–35.
Article
CAS
PubMed
Google Scholar
Fukuchi-mizutani M, Okuhara H, Fukui Y, Nakao M, Katsumoto Y, Yonekura-sakakibara K, et al. Biochemical and molecular characterization of a novel UDP-Glucose: Anthocyanin 3′-O-Glucosyltransferase, a key enzyme for blue anthocyanin biosynthesis, from gentian. Plant Physiol. 2003;132:1652–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jones P, Messner B, Nakajima J-I, Schäffner AR, Saito K. UGT73C6 and UGT78D1, glycosyltransferases involved in flavonol glycoside biosynthesis in Arabidopsis thaliana. J Biol Chem. 2003;278:43910–8.
Article
CAS
PubMed
Google Scholar
Zandalinas SI, Sales C, Beltrán J, Gómez-Cadenas A, Arbona V. Activation of secondary metabolism in citrus plants is associated to sensitivity to combined drought and high temperatures. Front Plant Sci. 2017;7:1954.
Article
PubMed
PubMed Central
Google Scholar
Liu X, Lin C, Ma X, Tan Y, Wang J, Zeng M. Functional characterization of a flavonoid glycosyltransferase in sweet orange (Citrus sinensis). Front Plant Sci. 2018;9:1–14.
Article
Google Scholar
Kita M, Hirata Y, Moriguchi T, Endo-inagaki T, Matsumoto R, Hasegawa S, et al. Molecular cloning and characterization of a novel gene encoding limonoid UDP-glucosyltransferase in Citrus. FEBS Press. 2000;469:173–8.
Article
CAS
Google Scholar
Daniel JJ, Owens DK, McIntosh CA. Secondary product glucosyltransferase and putative glucosyltransferase expression during Citrus paradisi (cv Duncan) growth and development. Phytochemistry. 2011;72:1732–8.
Article
CAS
PubMed
Google Scholar
Ito T, Fujimoto S, Suito F, Shimosaka M, Taguchi G. C-Glycosyltransferases catalyzing the formation of di-C-glucosyl flavonoids in citrus plants. Plant J. 2017;91:187–98.
Article
CAS
PubMed
Google Scholar
Huang D, Tang Z, Fu J, Yuan Y, Deng X, Xu Q. CsMYB3 and CsRuby1 form an ‘activator-and-repressor’loop for regulation of anthocyanin biosynthesis in citrus. Plant Cell Physiol. 2019;198:1–13. https://doi.org/10.1093/pcp/pcz198
Wang S, Yang C, Tu H, Zhou J, Liu X, Cheng Y, et al. Characterization and metabolic diversity of flavonoids in citrus species. Sci Rep. 2017;7:1–10.
Article
PubMed
PubMed Central
CAS
Google Scholar
Xuan L, Wang Z, Jiang L. Vanillin assay of Arabidopsis seeds for proanthocyanidins. Bio-protocol. 2014;4:e1309.
Article
Google Scholar
Butler LG, Price ML, Brotherton JE. Vanillin assay for proanthocyanidins (condensed tannins): modification of the solvent for estimation of the degree of polymerization. J Agric Food Chem. 1982;30:1087–9.
Article
CAS
Google Scholar
Deshpande SS, Cheryan M, Salunkhe DK, Luh BS. Tannin analysis of food products. Crit Rev Food Sci Nutr. 1986;24:401–49.
Article
CAS
PubMed
Google Scholar
Gonzalez A, Brown M, Hatlestad G, Akhavan N, Smith T, Hembd A, et al. TTG2 controls the developmental regulation of seed coat tannins in Arabidopsis by regulating vacuolar transport steps in the proanthocyanidin pathway. Dev Biol. 2016;419:54–63.
Article
CAS
PubMed
Google Scholar
Debeaujon I, Nesi N, Perez P, Devic M, Grandjean O, Caboche M, et al. Proanthocyanidin-accumulating cells in Arabidopsis testa: regulation of differentiation and role in seed development. Plant Cell. 2003;15:2514–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Routaboul J-M, Dubos C, Beck G, Marquis C, Bidzinski P, Loudet O, et al. Metabolite profiling and quantitative genetics of natural variation for flavonoids in Arabidopsis. J Exp Bot. 2012;63:3749–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Trojak M, Skowron E. Role of anthocyanins in high-light stress response. World Sci News. 2017;81:150–68.
CAS
Google Scholar
Hussain S, Khalid MF, Saqib M, Ahmad S, Zafar W, Rao MJ, et al. Drought tolerance in citrus rootstocks is associated with better antioxidant defense mechanism. Acta Physiol Plant. 2018;40:135.
Article
CAS
Google Scholar
Veal EA, Day AM, Morgan BA. Hydrogen peroxide sensing and signaling. Mol Cell. 2007;26:1–14.
Article
CAS
PubMed
Google Scholar
Kuźniak E, Urbanek H. The involvement of hydrogen peroxide in plant responses to stresses. Acta Physiol Plant. 2000;22:195–203.
Article
Google Scholar
Zaare-Nahandi F, Hosseinkhani S, Zamani Z, Asadi-Abkenar A, Omidbaigi R. Delay expression of limonoid UDP-glucosyltransferase makes delayed bitterness in citrus. Biochem Biophys Res Commun. 2008;371:59–62.
Article
CAS
PubMed
Google Scholar
Han S-I, Lee J, Kim MS, Chung SJ, Kim J-H. Molecular cloning and characterization of a flavonoid glucosyltransferase from Byungkyool (Citrus platymamma hort. ex Tanaka). Appl Biol Chem. 2017;60:49–55.
Article
CAS
Google Scholar
Huang Y, Si Y, Dane F. Impact of grafting on cold responsive gene expression in Satsuma mandarin (Citrus unshiu). Euphytica. 2011;177:25–32.
Article
CAS
Google Scholar
Lichtenthaler HK, Burkart S. Photosynthesis and high light stress. Bulg J Plant Physiol. 1999;25:3–16.
CAS
Google Scholar
Hasanuzzaman M, Hossain MA, da Silva JAT, Fujita M. Plant response and tolerance to abiotic oxidative stress: antioxidant defense is a key factor. Crop Stress Manage Perspect Strateg. 2012:261–315 Springer.
Close DC, Mcarthur C. Rethinking the role of many plant phenolics protection from photodamage not herbivores? OIKOS. 2002;1:166–72.
Article
CAS
Google Scholar
Karimi M, Inzé D, Depicker A. GATEWAY™ vectors for Agrobacterium-mediated plant transformation. Trends Plant Sci. 2002;7:193–5.
Article
CAS
PubMed
Google Scholar
Clough SJ, Bent AF. Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. Plant J. 1998;16:735–43.
Article
CAS
PubMed
Google Scholar
Kasajima I, Ide Y, Ohkama-Ohtsu N, Hayashi H, Yoneyama T, Fujiwara T. A protocol for rapid DNA extraction from Arabidopsis thaliana for PCR analysis. Plant Mol Biol Report. 2004;22:49–52.
Article
CAS
Google Scholar
Edwards K, Johnstone C, Thompson C. A simple and rapid method for the preparation of plant genomic DNA for PCR analysis. Nucleic Acids Res. 1991;19:1349.
Article
CAS
PubMed
PubMed Central
Google Scholar
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. Methods. 2001;25:402–8.
Article
CAS
PubMed
Google Scholar
Wang Z, Chen M, Chen T, Xuan L, Li Z, Du X, et al. TRANSPARENT TESTA 2 regulates embryonic fatty acid biosynthesis by targeting FUSCA 3 during the early developmental stage of Arabidopsis seeds. Plant J. 2014;77:757–69.
Article
CAS
PubMed
Google Scholar
Broadhurst RB, Jones WT. Analysis of condensed tannins using acidified vanillin. J Sci Food Agric. 1978;29:788–94.
Article
CAS
Google Scholar
Sumanta N, Haque CI, Nishika J, Suprakash R. Spectrophotometric analysis of chlorophylls and carotenoids from commonly grown fern species by using various extracting solvents spectrophotometric analysis of chlorophylls and carotenoids from commonly grown fern species by using various extracting solvents. Res J Chem Sci. 2014;4:63–9.
Google Scholar
Velioglu YS, Mazza G, Gao L, Oomah BD. Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products. J Agric Food Chem. 1998;46:4113–7.
Article
CAS
Google Scholar
Dewanto V, Wu X, Adom KK, Liu RH. Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity. J Agric Food Chem. 2002;50:3010–4.
Article
CAS
PubMed
Google Scholar
Nakata M, Mitsuda N, Herde M, Koo AJK, Moreno JE, Suzuki K, et al. A bHLH-type transcription factor, ABA-inducible bHLH-type transcription factor/JA-associated MYC2-LIKE1, acts as a repressor to negatively regulate jasmonate signaling in Arabidopsis. Plant Cell. 2013;25:1641–56.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nakata M, Ohme-Takagi M. Quantification of anthocyanin content. Bio-protocol. 2014;4:e1098.
Google Scholar
Özgen M, Scheerens JC, Reese RN, Miller RA. Total phenolic, anthocyanin contents and antioxidant capacity of selected elderberry (Sambucus canadensis L.) accessions. Pharmacogn Mag. 2010;6:198.
Article
PubMed
PubMed Central
CAS
Google Scholar
Velikova V, Yordanov I, Edreva A. Oxidative stress and some antioxidant systems in acid rain-treated bean plants: protective role of exogenous polyamines. Plant Sci. 2000;151:59–66.
Article
CAS
Google Scholar
Feng Y, Zhang M, Guo Q, Wang G, Gong J, Xu Y, et al. Manipulation of mono-ubiquitin improves chilling tolerance in transgenic tobacco (Nicotiana tabacum). Plant Physiol Biochem. 2014;75:138–44.
Article
CAS
PubMed
Google Scholar