Liu WC, Gong T, Zhu P. ChemInform abstract: advances in exploring alternative Taxol sources. RSC Adv. 2016;6(54):48800–9.
Article
CAS
Google Scholar
Thornburg CK, Walter T, Walker KD. Biocatalysis of a paclitaxel analogue: conversion of baccatin III to N-debenzoyl-N-(2-furoyl)paclitaxel and characterization of an amino phenylpropanoyl CoA transferase. Biochemistry. 2017;56(44):5920–30.
Article
CAS
PubMed
Google Scholar
Onrubia M, Moyano E, Bonfill M, Palazon J, Goossens A, Cusido RM. The relationship between TXS, DBAT, BAPT and DBTNBT gene expression and taxane production during the development of Taxus baccata plantlets. Plant Sci. 2011;181(3):282–7.
Article
CAS
PubMed
Google Scholar
Guerra-Bubb J, Croteau R, Williams RM. The early stages of taxol biosynthesis: an interim report on the synthesis and identification of early pathway metabolites. Nat Prod Rep. 2012;29(6):683–96.
Article
CAS
PubMed
PubMed Central
Google Scholar
Croteau R, Ketchum RE, Long RM, Kaspera R, Wildung MR. Taxol biosynthesis and molecular genetics. Phytochem Rev. 2006;5(1):75–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ketchum RE, Horiguchi T, Qiu D, Williams RM, Croteau RB. Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway. Phytochemistry. 2007;68(3):335–41.
Article
CAS
PubMed
Google Scholar
Li C, Huo C, Zhang M, Shi Q. Chemistry of Chinese yew, Taxus chinensis var. mairei. Biochem Systematics Ecol. 2008;36(4):266–82.
Article
CAS
Google Scholar
Eisenreich W, Menhard B, Hylands PJ, Zenk MH, Bacher A. Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin. Proc Natl Acad Sci U S A. 1996;93(13):6431–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vranova E, Coman D, Gruissem W. Network analysis of the MVA and MEP pathways for isoprenoid synthesis. Annu Rev Plant Biol. 2013;64:665–700.
Article
CAS
PubMed
Google Scholar
Harrison JW, Scrowston RM, Lythgoe B, Harrison JW, Scrowston RM, Lythgoe B. Taxine. Part IV. The constitution of taxine-I. J Chem Soc C Org. 1966:1933–45.
Williams DC, Wildung MR, Jin AQ, Dalal D, Oliver JS, Coates RM, et al. Heterologous expression and characterization of a “Pseudomature” form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep Diterpene cyclization reaction. Arch Biochem Biophys. 2000;379(1):137–46.
Article
CAS
PubMed
Google Scholar
Lee YH, Lee YR, Park CS, Im SA, Song S, Hong JT, et al. Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice. Int Immunopharmacol. 2014;21(2):487–93.
Article
CAS
PubMed
Google Scholar
Jiménez-Barbero J, Amat-Guerri F, Snyder JP. The solid state, solution and tubulin-bound conformations of agents that promote microtubule stabilization. Curr Med Chem Anticancer Agents. 2002;2(1):91–122.
Article
PubMed
Google Scholar
Wang YF, Shi QW, Dong M, Kiyota H, Gu YC, Cong B. Natural taxanes: developments since 1828. Chem Rev. 2011;111(12):7652–709.
Article
CAS
PubMed
Google Scholar
Shi Q, Oritani T, Sugiyama T, Murakami R, Wei H. Six new taxane diterpenoids from the seeds of Taxus chinensis var. mairei and Taxus yunnanensis. J Nat Prod. 1999;62(8):1114–8.
Article
CAS
PubMed
Google Scholar
Yang L, Zheng ZS, Cheng F, Ruan X, Jiang DA, Pan CD, et al. Seasonal dynamics of metabolites in needles of Taxus wallichiana var. mairei. Molecules. 2016;21(10):1403.
Article
PubMed Central
CAS
Google Scholar
Zu Y, Fu Y, Li S, Sun R, Li Q, Schwarz G. Rapid separation of four main taxoids in Taxus species by a combined LLP-SPE-HPLC (PAD) procedure. J Sep Sci. 2006;29(9):1237–44.
Article
CAS
PubMed
Google Scholar
Li S, Fu Y, Zu Y, Sun R, Wang Y, Zhang L, et al. Determination of paclitaxel and other six taxoids in Taxus species by high-performance liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2009;49(1):81–9.
Article
PubMed
CAS
Google Scholar
Wang LY, Ding LM, Huo SC, Sun L, Sun Z. Three new taxoids from the seed of Taxus cuspidata. J Nat Med. 2013;67(4):827–32.
Article
CAS
PubMed
Google Scholar
Itokawa H, Lee KH. Taxus : the genus Taxus: Taylor & Francis; 2003.
Google Scholar
Poupat C, Hook I, Gueritte F, Ahond A, Guenard D, Adeline MT, et al. Neutral and basic taxoid contents in the needles of Taxus species. Planta Med. 2000;66(6):580–4.
Article
CAS
PubMed
Google Scholar
Lommen A, van der Weg G, van Engelen MC, Bor G, Hoogenboom LA, Nielen MW. An untargeted metabolomics approach to contaminant analysis: pinpointing potential unknown compounds. Anal Chim Acta. 2007;584(1):43–9.
Article
CAS
PubMed
Google Scholar
Ketchum RE, Rithner CD, Qiu D, Kim YS, Williams RM, Croteau RB. Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures. Phytochemistry. 2003;62(6):901–9.
Article
CAS
PubMed
Google Scholar
Tanaka K, Li F, Morikawa K, Nobukawa T, Kadota S. Analysis of biosynthetic fluctuations of cultured Taxus seedlings using a metabolomic approach. Phytochemistry. 2011;72(14–15):1760–6.
Article
CAS
PubMed
Google Scholar
Zheng W, Komatsu S, Zhu W, Zhang L, Li X, Cui L, et al. Response and defense mechanisms of Taxus chinensis leaves under UV-A radiation are revealed using comparative proteomics and metabolomics analyses. Plant & cell physiology. 2016;57(9):1839–53.
Article
CAS
Google Scholar
Jin J, Zhang H, Zhang J, Liu P, Chen X, Li Z, et al. Integrated transcriptomics and metabolomics analysis to characterize cold stress responses in Nicotiana tabacum. BMC Genomics. 2017;18(1):496.
Article
PubMed
PubMed Central
CAS
Google Scholar
Xu Q, Zhu J, Zhao S, Hou Y, Li F, Tai Y, et al. Transcriptome profiling using single-molecule direct RNA sequencing approach for in-depth understanding of genes in secondary metabolism pathways of Camellia sinensis. Front Plant Sci. 2017;8:1205.
Article
PubMed
PubMed Central
Google Scholar
Hao da C, Huang B, Yang L. Phylogenetic relationships of the genus Taxus inferred from chloroplast intergenic spacer and nuclear coding DNA. Biol Pharm Bull. 2008;31(2):260–5.
Article
PubMed
Google Scholar
van Rozendaal EL, Lelyveld GP, van Beek TA. Screening of the needles of different yew species and cultivars for paclitaxel and related taxoids. Phytochemistry. 2000;53(3):383–9.
Article
PubMed
Google Scholar
Howat S, Park B, Oh IS, Jin YW, Lee EK, Loake GJ. Paclitaxel: biosynthesis, production and future prospects. New Biotechnol. 2014;31(3):242–5.
Article
CAS
Google Scholar
Hao J, Guo H, Shi X, Wang Y, Wan Q, Song Y, et al. Comparative proteomic analyses of two Taxus species (Taxus × media and Taxus mairei) reveals variations in the metabolisms associated with paclitaxel and other metabolites. Plant Cell Physiol. 2017;114(24):6388.
Google Scholar
Shen YC, Chen CY. Taxane diterpenes from Taxus mairei. Planta Med. 1997;63(6):569–70.
Article
CAS
PubMed
Google Scholar
Ohtsuki K, Miyai S, Yamaguchi A, Morikawa K, Okano T. Biochemical characterization of novel lignans isolated from the wood of Taxus yunnanensis as effective stimulators for glycogen synthase kinase-3beta and the phosphorylation of basic brain proteins by the kinase in vitro. Biol Pharm Bull. 2012;35(3):385–93.
Article
CAS
PubMed
Google Scholar
Yu J, Wang Y, Qian H, Zhao Y, Liu B, Fu C. Polyprenols from the needles of Taxus chinensis var. mairei. Fitoterapia. 2012;83(5):831–7.
Article
CAS
PubMed
Google Scholar
Tang W, Hazebroek J, Zhong C, Harp T, Vlahakis C, Baumhover B, et al. Effect of genetics, environment, and phenotype on the metabolome of maize hybrids using GC/MS and LC/MS. J Agric Food Chem. 2017;65(25):5215–25.
Article
CAS
PubMed
Google Scholar
Aversano R, Contaldi F, Adelfi MG, D'Amelia V, Diretto G, De Tommasi N, et al. Comparative metabolite and genome analysis of tuber-bearing potato species. Phytochemistry. 2017;137:42–51.
Article
CAS
PubMed
Google Scholar
Hefner J, Rubenstein SM, Ketchum RE, Gibson DM, Williams RM, Croteau R. Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis. Chem Biol. 1996;3(6):479–89.
Article
CAS
PubMed
Google Scholar
Nevarez DM, Mengistu YA, Nawarathne IN, Walker KD. An N-aroyltransferase of the BAHD superfamily has broad aroyl CoA specificity in vitro with analogues of N-dearoylpaclitaxel. J Am Chem Soc. 2009;131(16):5994–6002.
Article
CAS
PubMed
Google Scholar
Kaspera R, Croteau R. Cytochrome P450 oxygenases of Taxol biosynthesis. Phytochem Rev. 2006;5(2–3):433–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Alder JD, Jarvis KP, Marsh KC, Klein LL, Clement JJ. Preclinical in vivo efficacy of two 9-dihydrotaxane analogues against human and murine tumours. Br J Cancer. 1996;73(5):560–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Distefano M, Scambia G, Ferlini C, Gaggini C, De Vincenzo R, Riva A, et al. Anti-proliferative activity of a new class of taxanes (14beta-hydroxy-10-deacetylbaccatin III derivatives) on multidrug-resistance-positive human cancer cells. Int J Cancer. 1997;72(5):844–50.
Article
CAS
PubMed
Google Scholar
Bulgakov VP, Tchernoded GK, Veselova MV, Fedoreyev SA, Muzarok TI, Zhuravlev YN. Catechin production in cultured cells of Taxus cuspidata and Taxus baccata. Biotechnol Lett. 2011;33(9):1879–83.
Article
CAS
PubMed
Google Scholar
Zhang M, Dong Y, Nie L, Lu M, Fu C, Yu L. High-throughput sequencing reveals miRNA effects on the primary and secondary production properties in long-term subcultured Taxus cells. Front Plant Sci. 2015;6:604.
PubMed
PubMed Central
Google Scholar
Rezaei A, Ghanati F, Behmanesh M, Mokhtari-Dizaji M. Ultrasound-potentiated salicylic acid-induced physiological effects and production of taxol in hazelnut (Corylus avellana L.) cell culture. Ultrasound Med Biol. 2011;37(11):1938–47.
Article
PubMed
Google Scholar
Kuang X, Sun S, Wei J, Li Y, Sun C. Iso-Seq analysis of the Taxus cuspidata transcriptome reveals the complexity of Taxol biosynthesis. BMC Plant Biol. 2019;19(1):210.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhou T, Luo X, Yu C, Zhang C, Zhang L, Song Y-B, et al. Transcriptome analyses provide insights into the expression pattern and sequence similarity of several taxol biosynthesis-related genes in three Taxus species. BMC Plant Biol. 2019;19(1):33.
Article
PubMed
PubMed Central
Google Scholar
Zhao L, Gao L, Wang H, Chen X, Wang Y, Yang H, et al. The R2R3-MYB, bHLH, WD40, and related transcription factors in flavonoid biosynthesis. Funct Integr Genomics. 2013;13(1):75–98.
Article
CAS
PubMed
Google Scholar
Ohno S, Hosokawa M, Hoshino A, Kitamura Y, Morita Y, Park KI, et al. A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). J Exp Bot. 2011;62(14):5105–16.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lenka SK, Nims NE, Vongpaseuth K, Boshar RA, Roberts SC, Walker EL. Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4. Front Plant Sci. 2015;6:115.
Article
PubMed
PubMed Central
Google Scholar
Smith CA, Want EJ, O'Maille G, Abagyan R, Siuzdak G. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem. 2006;78(3):779–87.
Article
CAS
PubMed
Google Scholar
Yu C, Guo H, Zhang Y, Song Y, Pi E, Yu C, et al. Identification of potential genes that contributed to the variation in the taxoid contents between two Taxus species (Taxus media and Taxus mairei). Tree Physiol. 2017;37(12):1659–71.
Article
CAS
PubMed
Google Scholar