Domain organization of Arabidopsis RanBPM protein and its plant and human homologues. A- AtRanBPM protein consists of highly conserved SPRY, LisH, CTLH, and CRA domains. B- Comparison of AtRanBPM protein with its closest plant homologues. Rco – Ricinus communis, Vvi – Vitis vinifera, Ptr – Populus trichocarpa, Sbi – Sorghum bicolor, Osa – Oryza sativa, Zma – Zea mays. C- Comparison of AtRanBPM protein with its closest human homologues. Bold black lines indicate the 150 amino acids insertion between CTLH and CRA domains present only in human but not in plant RanBPM proteins. RanBPM90 – RanBPM of 90 kDa, RanBPM55 – RanBPM of 55 kDa.