Environment-modulated network of additive main-effect and interacting QTL controls isoflavone accumulation. Blue ovals indicate additive main-effect loci associated with genistein, red ovals indicate loci associated with daidzein, green ovals indicate loci associated with glycitein and brown ovals indicate loci associated with total isoflavones. The name of the QTL, shown aside each oval, is a composite of the influenced trait: genistein (GEN), daidzein (DAI), glycitein (GLY) and total of isoflavones (TOT), followed by the chromosome number. Red squares surround the loci with effect-by-environment interaction, i.a. QTL with a significant additive component but also significantly different at each environment. In an effort to make the map more informative QTL reported for ours and other groups: yellow squares , light-orange , and light-blue squares . Lines indicate en epistatic interaction between the interconnected genomic regions, maintaining the same color codes than for additive QTLs: blue for genistein, red for daidzein, green for glycitein, and brown for total isoflavone content. Dotted lines reflect epistasis with effect-by-environment interaction component. Genomic locations of candidate genes for isoflavone synthesis are located on the chromosomes by a red arrow and their abbreviated name.