Table 8 Summary of secondary metabolite gene clusters mined by AntiSmash2.0 in Bacillus subtilis PBs12 and Bacillus paralicheniformis PBl36

Bacillus subtilis PBs12

Bacillus paralicheniformis PBl36

Alkaloid

7521

NRP

13328

Alkaloid + Polyketide:Modular type I

4797

Alkaloid

5341

NRP

4283

Alkaloid + NRP

2753

NRP + Alkaloid

962

Alkaloid + NRP:Lipopeptide

916

NRP + Alkaloid + Polyketide:Iterative type I

646

Alkaloid + NRP + Polyketide:Iterative type I polyketide

850

NRP + Alkaloid + Polyketide:Modular type I

503

Alkaloid + Polyketide

837

NRP + Polyketide

492

Alkaloid + Polyketide:Modular type I polyketide

808

NRP + Polyketide:Enediyne type I

457

Alkaloid + RiPP + Terpene

741

NRP + Polyketide:Iterative type I

396

Alkaloid + Terpene + Saccharide

565

NRP + Polyketide:Modular type I

391

NRP:Beta-lactam

487

NRP + Polyketide:Modular type I + Polyketide:PUFA synthase or related

371

NRP:Beta-lactam + Polyketide:Type II polyketide

475

NRP + Polyketide:Modular type I + Polyketide:Trans-AT type I

327

NRP:Cyclic depsipeptide

435

NRP + Polyketide:Modular type I + Saccharide:Hybrid/tailoring

308

NRP:Cyclic depsipeptide + Polyketide:Iterative type I polyketide

414

NRP + Polyketide:Trans-AT type I

307

NRP:Cyclic depsipeptide + Polyketide:Modular type I polyketide

351

NRP + RiPP

297

NRP:Cyclic depsipeptide + Polyketide:Trans-AT type I polyketide

269

NRP + Saccharide:Hybrid/tailoring

277

NRP:Glycopeptide

255

NRP + Terpene

261

NRP:Glycopeptide + Polyketide:Modular type I polyketide + Saccharide:Hybrid/tailoring saccharide

253

NRP + Terpene + Alkaloid

203

NRP:Glycopeptide + Polyketide:Other polyketide + Saccharide:Hybrid/tailoring saccharide

235

NRP:Beta-lactam

196

NRP:Glycopeptide + Saccharide:Hybrid/tailoring saccharide

227

NRP:Beta-lactam + Polyketide:Modular type I

150

NRP:Lipopeptide

208

NRP:Beta-lactam + Polyketide:Type II

126

NRP:Lipopeptide:Ca + -dependent lipopeptide

176

NRP:Ca + -dependent lipopeptide

114

NRP:Lipopeptide + Polyketide:Iterative type I polyketide

174

NRP:Cyclic depsipeptide

112

NRP:Lipopeptide + Polyketide:Modular type I polyketide

168

NRP:Cyclic depsipeptide + Polyketide:Iterative type I

104

NRP:Lipopeptide + Polyketide:Modular type I polyketide + Saccharide:Hybrid/tailoring saccharide

143

NRP:Cyclic depsipeptide + Polyketide:Modular type I

96

NRP:Lipopeptide + Polyketide:Trans-AT type I polyketide

119

NRP:Cyclic depsipeptide + Polyketide:Trans-AT type I

91

NRP:Lipopeptide + Saccharide:Hybrid/tailoring saccharide

117

NRP:Glycopeptide

85

NRP:NRP siderophore

112

NRP:Glycopeptide + Polyketide:Modular type I + Saccharide:Hybrid/tailoring

84

NRP:NRP siderophore + Polyketide:Modular type I polyketide + Polyketide:Iterative type I polyketide

109

NRP:Glycopeptide + Polyketide:Other + Saccharide:Hybrid/tailoring

83

NRP:Pyrrolobenzodiazepine

92

NRP:Glycopeptide + Saccharide:Hybrid/tailoring

82

NRP:Uridylpeptide + Other:Nucleoside

88

NRP:Lipopeptide

76

NRP + Alkaloid

85

NRP:Lipopeptide + Polyketide:Iterative type I

73

NRP + Alkaloid + Polyketide:Iterative type I polyketide

84

NRP:Lipopeptide + Polyketide:Modular type I

67

NRP + Alkaloid + Polyketide:Modular type I polyketide

79

NRP:Lipopeptide + Polyketide:Modular type I + Saccharide:Hybrid/tailoring

63

NRP + Other

76

NRP:Lipopeptide + Polyketide:Trans-AT type I

53

NRP + Polyketide

73

NRP:Lipopeptide + Saccharide:Hybrid/ tailoring

49

NRP + Polyketide:Enediyne type I polyketide

64

NRP:NRP siderophore

44

NRP + Polyketide:Iterative type I polyketide

62

NRP:NRP siderophore + Polyketide:Modular type I + Polyketide:Iterative type I

42

NRP + Polyketide:Iterative type I polyketide + Polyketide:Enediyne type I polyketide

61

NRP:Uridylpeptide + Other:Nucleoside

31

NRP + Polyketide:Modular type I polyketide

60

Other

30

NRP + Polyketide:Modular type I polyketide + Polyketide:PUFA synthase or related polyketide

55

Other:Aminocoumarin

30

NRP + Polyketide:Modular type I polyketide + Polyketide:Trans-AT type I polyketide

54

Other:Cyclitol

30

NRP + Polyketide:Modular type I polyketide + Saccharide:Hybrid/tailoring saccharide

49

Other:Non-NRP beta-lactam

29

NRP + Polyketide:Trans-AT type I polyketide

47

Other:Nucleoside

29

NRP + Polyketide:Type II polyketide + Saccharide:Hybrid/tailoring saccharide

44

Other:Phenazine

29

NRP + Polyketide + Other

41

Other:Shikimate-derived

29

NRP + Polyketide + Saccharide

35

Polyketide

27

NRP + RiPP

35

Polyketide + NRP

26

NRP + Saccharide

35

Polyketide + NRP + Other:Aminocoumarin

26

NRP + Saccharide:Hybrid/tailoring saccharide

32

Polyketide + NRP + Other:Shikimate-derived

24

NRP + Terpene

32

Polyketide + NRP:Cyclic depsipeptide

24

NRP + Terpene + Alkaloid

30

Polyketide + NRP:Cyclic depsipeptide + Other:Aminocoumarin

23

Other

29

Polyketide + NRP:Lipopeptide

23

Other:Aminocoumarin

28

Polyketide + Other:Aminocoumarin

22

Other:Cyclitol

22

Polyketide + Other:Cyclitol

22

Other:Ectoine

22

Polyketide + Saccharide:Hybrid/tailoring

21

Other:Fatty acid

21

Polyketide + Terpene

18

Other:Non-NRP beta-lactam

21

Polyketide:Iterative type I

17

Other:Non-NRP siderophore

21

Polyketide:Iterative type I + Polyketide:Enediyne type I

17

Other:Nucleoside

21

Polyketide:Iterative type I + Polyketide:Trans-AT type I

16

Other:Phenazine

20

Polyketide:Iterative type I + Polyketide:Type II + Saccharide:Hybrid/tailoring

16

Other:shikimate derived

20

Polyketide:Iterative type I + Saccharide:Hybrid/tailoring

15

Other:Shikimate-derived

20

Polyketide:Modular type I

14

Other + Polyketide

20

Polyketide:Modular type I + Polyketide:Iterative type I + Saccharide:Oligosaccharide

14

Other + Saccharide

19

Polyketide:Modular type I + Polyketide:Trans-AT type I

13

Polyketide

19

Polyketide:Modular type I + Polyketide:Type III

13

Polyketide:Iterative type I polyketide

18

Polyketide:Modular type I + Saccharide:Hybrid/tailoring

13

Polyketide:Iterative type I polyketide + Polyketide:Enediyne type I polyketide

17

Polyketide:Trans-AT type I

13

Polyketide:Iterative type I polyketide + Polyketide:Trans-AT type I polyketide

16

Polyketide:Type II

13

Polyketide:Iterative type I polyketide + Polyketide:Type II polyketide + Saccharide:Hybrid/tailoring saccharide

16

Polyketide:Type II + Polyketide:Type III

13

Polyketide:Iterative type I polyketide + Saccharide:Hybrid/tailoring saccharide

16

Polyketide:Type II + Saccharide:Hybrid/tailoring

12

Polyketide:Modular type I polyketide

15

Polyketide:Type II + Saccharide:Oligosaccharide

11

Polyketide:Modular type I polyketide + Polyketide:Iterative type I polyketide + Saccharide:Oligosaccharide

15

RiPP

11

Polyketide:Modular type I polyketide + Polyketide:Trans-AT type I polyketide

14

RiPP:Bottromycin

10

Polyketide:Modular type I polyketide + Polyketide:Type III polyketide

14

RiPP:Cyanobactin

9

Polyketide:Modular type I polyketide + Saccharide:Hybrid/tailoring saccharide

14

RiPP:Glycocin

9

Polyketide:Trans-AT type I polyketide

13

RiPP:Head-to-tailcyclized peptide

9

Polyketide:Type II polyketide

13

RiPP:Lanthipeptide

9

Polyketide:Type II polyketide + Polyketide:Type III polyketide

13

RiPP:LAP

8

Polyketide:Type II polyketide + Saccharide:Hybrid/tailoring saccharide

13

RiPP:Lassopeptide

7

Polyketide:Type II polyketide + Saccharide:Oligosaccharide

12

RiPP:Linaridin

7

Polyketide + Alkaloid

12

RiPP:Microcin

7

Polyketide + NRP

12

RiPP:Microviridin

7

Polyketide + NRP:Cyclic depsipeptide

12

RiPP:Proteusin

7

Polyketide + NRP:Cyclic depsipeptide + Other:Aminocoumarin

11

RiPP:Sactipeptide

6

Polyketide + NRP:Glycopeptide + Saccharide:Hybrid/tailoring saccharide

11

RiPP:Thiopeptide

5

Polyketide + NRP:Lipopeptide

11

Saccharide

5

Polyketide + NRP + Other

10

Saccharide + NRP

5

Polyketide + NRP + Other:Aminocoumarin

10

Saccharide + NRP:Glycopeptide

5

Polyketide + NRP + Other:Shikimate-derived

10

Saccharide + Polyketide

4

Polyketide + NRP + Saccharide

10

Saccharide + Polyketide:Modular type I + Polyketide:Type II + Other:Aminocoumarin

4

Polyketide + Other

9

Saccharide:Aminoglycoside

4

Polyketide + Other:Aminocoumarin

9

Saccharide:Exopolysaccharide

3

Polyketide + Saccharide

9

Saccharide:Hybrid/tailoring

3

Polyketide + Saccharide:Hybrid/tailoring saccharide

9

Saccharide:Hybrid/tailoring + Other:Aminocoumarin

3

Polyketide + Saccharide:Oligosaccharide

9

Saccharide:Lipopolysaccharide

3

Polyketide + Terpene

9

Saccharide:Oligosaccharide

3

Polyketide + Terpene + Alkaloid

9

Terpene

3

RiPP

9

Terpene + Alkaloid

2

RiPP:Bottromycin

9

Terpene + Polyketide

2

RiPP:Cyanobactin

7

Terpene + Polyketide:Iterative type I

2

RiPP:Glycocin

7

Terpene + Polyketide:Type III

1

RiPP:Head-to-tailcyclized peptide

6

Terpene + RiPP:Glycocin

1

RiPP:Lanthipeptide

6

Terpene + Saccharide

1

RiPP:LAP

6

Terpene + Saccharide:Hybrid/tailoring

1

RiPP:Lassopeptide

6

RiPP:Linaridin

5

RiPP:Microcin

5

RiPP:Microviridin

5

RiPP:Other

5

RiPP:Proteusin

5

RiPP:Sactipeptide

4

RiPP:Thiopeptide

4

RiPP + Alkaloid

4

Saccharide

4

Saccharide:Aminoglycoside

3

Saccharide:Hybrid/tailoring saccharide

3

Saccharide:Hybrid/tailoring saccharide + Other:Aminocoumarin

3

Saccharide:Hybrid/tailoring saccharide + Other:Nucleoside

2

Saccharide:Lipopolysaccharide

2

Saccharide:Oligosaccharide

2

Saccharide + NRP

2

Saccharide + NRP:Glycopeptide

2

Saccharide + Other:Cyclitol

1

Saccharide + Polyketide

1

Saccharide + Polyketide:Modular type I polyketide + Polyketide:Type II polyketide + Other:Aminocoumarin

1

Terpene

1

Terpene + Alkaloid

1

Terpene + NRP

1

Terpene + Polyketide:Iterative type I polyketide

1

Terpene + Polyketide:Type III polyketide

1

Terpene + RiPP:Glycocin

1

Terpene + Saccharide

1

Terpene + Saccharide:Hybrid/tailoring saccharide

1

Total

25458

33000