Fig. 7
The STRING based protein–protein interaction network for both upregulated and the down-regulated genes. a PPI network for the topmost 25 genes with significant expression (padj < 0.05; pcal < 0.05 and pcal < 0.01and FC > 1). The colored ball indicated the genes/nodes along with edges. The differently colored ball indicated the shared contribution of each and every node with different proteins based on GO biological process involved. The k means clustering algorithm separated the entire PPI network into three different clusters and the separted clusters are shown with dotted line along the edges. b PPI network for the downregulated 25 genes with significant expression (padj < 0.05; pcal < 0.05 and pcal < 0.01, and FC < 1). The colored ball indicated the genes/nodes along with edges. The differently colored ball indicated the shared contribution of each and every node with different proteins based on GO biological process involved