Fig. 5

Protein-protein interaction (PPI) network of differentially accumulated proteins identified in the proteome. a PPI network constructed using the differentially accumulated proteins. Number of nodes: 345; number of edges: 1101; average node degree: 4.63; avg. local clustering coefficient: 0.321; expected number of edges: 971; PPI enrichment p-value: 2.35E-05. The red nodes stand for proteins with higher abundance in gwt1, while the green nodes stand for lower abundant proteins in gwt1. b-d The significant modules were retrieved from the PPI network using the molecular complex detection (MCODE) method with a score of ≥ 5.0. b shows module 1 with an MCODE score of 15.750, c shows module 2 with an MCODE score of 6.380, and d shows module 2 with an MCODE score of 5.667. The red nodes stand for proteins with higher abundance in gwt1, while the green nodes stand for lower abundant proteins in gwt1