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Table 2 54 differential compounds (healthy vs SLCMV-infected groups) in all three cassava cultivars (TME3, KU50, and R11) and annotated in KEGG pathway analysis. The compound labels are from the KEGG database or other references (as mentioned in the table). The table is based on comma separated values (.csv) files. mes- is the KEGG ID for the Manihot esculenta (cassava) model organism

From: Metabolic profiles of Sri Lankan cassava mosaic virus-infected and healthy cassava (Manihot esculenta Crantz) cultivars with tolerance and susceptibility phenotypes

Compounds name

KEGG ID and others

Metabolic pathways

p.value

FDR

-log10(p)

p-coumaric acid

C00811

-Ubiquinone and other terpenoid-quinone biosynthesis, Tyrosine metabolism and

9.8287E-21

5.3075E-19

20.008

  

-Biosynthesis of phenylpropanoids

   

Ferulic acid

mesc01100

-Phenylpropanoid biosynthesisc

1.0714E-18

2.8928E-17

17.97

L-Phenylalanine

C00079, mesc00960 and mesc00460

-Tropane, piperidine and pyridine alkaloid biosynthesis.  -Cyanoamino acid metabolism

2.809E-18

5.0562E-17

17.551

Caffeic acid

C01197

-Phenylpropanoid biosynthesis and Biosynthesis of phenylpropanoids

5.4956E-18

7.4191E-17

17.26

Kaempferol

C05903 and mesc00941

-Flavonoid biosynthesis

1.8769E-16

1.9135E-15

15.727

DL-Tryptophan

C00078

-Phenylalanine, tyrosine, and tryptophan biosynthesis

2.1261E-16

1.9135E-15

15.672

 

-Aminoacyl-tRNA biosynthesis

   
 

-Glycine, serine, and threonine metabolism

   

L-Asparagine

C00152 and mesc01230

-Biosynthesis of amino acids

8.2644E-16

6.3754E-15

15.083

DL-Arginine

C00062 and mesc01230

-Biosynthesis of amino acids

1.5382E-15

9.7835E-15

14.813

L-(-)-Serine

C00065 and mesc01230

-Biosynthesis of amino acids

1.6306E-15

9.7835E-15

14.788

L-Histidine

C00135, mesc01230 and mesc02010

-Biosynthesis of amino acids and ABC transporters

2.7682E-15

1.3869E-14 

14.558

trans-3-Indoleacrylic acid

PubChemCID5375048a

-Tryptophan metabolism

2.8252E-15

1.3869E-14

14.549

L-Leucine

C00123 and mesc01230

-Biosynthesis of amino acids

9.1396E-15

4.1128E-14

14.039

DL-Glutamine

PubChemCID738a

-Peptidoglycan cytoplasmic synthesis and recycling pathways

2.8017E-14

1.1638E-13

13.553

Myricetin

C10107, mesc00944 and mesc00941

-Flavonoid biosynthesis

7.9059E-14

3.0494E-13

13.102

Rutin

C05625, mesc00944 and mesc00941

-Flavone and flavonol biosynthesis

1.2223E-13

4.4001E-13

12.913

L-Isoleucine

C00407 and mesc01230

-Biosynthesis of amino acids

2.1915E-13

6.9614E-13

12.659

L-Pyroglutamic acid

C01879

-Glutathione metabolism

2.8449E-13

8.5348E-13

12.546

Hyperoside

C10073

-Flavone and flavonol biosynthesis

5.1965E-13

1.4769E-12

12.284

Kaempferol-3-O-rutinoside

C21833

-Flavone and flavonol biosynthesis

6.6022E-13

1.7826E-12

12.18

Tran-ferulic acid

-

-Phenylpropanoidsb

7.7382E-13

1.9898E-12

12.111

Trifolin

mesc00944

-Flavone and flavonol biosynthesis

9.7426E-13

2.3914E-12

12.011

Mauritianin

C10178

-Flavone and flavonol biosynthesis

1.5242E-12

3.5786E-12

11.817

Rhamnetin

C10176

-Flavone and flavonol biosynthesis

1.8069E-12

4.0655E-12

11.743

Adenine

C00147 and mesc01232

-Nucleotide metabolism

2.2669E-12

4.8964E-12

11.645

D-(-)-Aspartic acid

C00402

-Biosynthesis of amino acids

2.7206E-12

5.6437E-12

11.565

Gallic acid

C01424

-Aminobenzoate degradation and biosynthesis of phenylpropanoids

2.8218E-12

5.6437E-12

11.549

DL-Lysine

PubChemCID866a

- Amino acid and derivativesb

5.0739E-12

9.7854E-12

11.295

Adenosine

C00212 and mesc01232

-Nucleotide metabolism

6.2633E-12

1.1663E-11

11.203

Citric acid

C00158

-Glutamate metabolism and Citrate cycle (TCA cycle) and Alanine aspartate

1.3109E-11

2.3597E-11

10.882 

Quercetin

C00389

-Flavone and flavonol biosynthesis

1.537E-11

2.6773E-11

10.813

L-Threonine

C00188, mesc00290 and mesc01230

-Biosynthesis of amino acids, valine, leucine, and isoleucine biosynthesis

2.6953E-11

4.5483E-11

10.569

N-Acetylmuramic acid

C02713

-Biosynthesis of nucleotide sugars and Phosphotransferase system (PTS) and Amino sugar and nucleotide sugar metabolism

4.9555E-11

8.1091E-11

10.305

L-Glutamic acid

C00025

-Alanine, proline, aspartate, and glutamate metabolism Aminoacyl-tRNA biosynthesis

5.7894E-11

9.195E-11

10.237

L-Tyrosine

C00082, mesc00970, mesc00360 and mesc00730

- Aminoacyl-tRNA biosynthesis and Phenylalanine metabolism andThiamine metabolism

6.344E-11

9.7879E-11

10.198

Pipecolic acid

C00408

- Lysine degradation and Tropane and Piperidine and pyridine alkaloid biosynthesis

9.1537E-11

1.373E-10 

10.038

4-Guanidinobutyric acid

C01035

-Arginine and proline metabolism

1.6724E-10

2.4407E-10

9.7767

Luteolin

C01514 and mesc00941

-Flavone and flavonol biosynthesis

4.6938E-10

6.6702E-10

9.3285

Valine

C00183, mesc00290 and mesc00280

-Valine, leucine and isoleucine biosynthesis and degradation

1.6357E-09

2.2285E-09

8.7863

Choline

C00114, mesc02010 and mesc00260

-ABC transporters and Glycine, serine, and threonine metabolism

1.6508E-09

2.2285E-09

8.7823

Trigonelline

mesc00960

-Tropane, piperidine and pyridine alkaloid biosynthesis

3.6166E-09

4.7634E-09

8.4417

D-(-)-Quinic acid

C00296

-Phenylalanine, tyrosine, and tryptophan biosynthesis

1.6833E-08

2.1643E-08

7.7738

Tricine

PubChemCID79784a

Other

4.0104E-08

5.0363E-08

7.3968

Vitamin C

C00072

- Ascorbate and aldarate metabolismd,c and Glutathione metabolism

2.3659E-07

2.9036E-07 

6.626

(2R)-dihomocitric acid

C16583, mjv01210 and mjv01240 

- 2-Oxocarboxylic acid metabolism and Biosynthesis of cofactors

1.4856E-06

1.7827E-06

5.8281

D-Glucose 6-phosphate

C00092 and mesc00500

-Starch and sucrose metabolism

2.6351E-06

3.0934E-06

5.5792

APM

HMDB0034252b

-Organic acids and derivatives

4.9873E-06

5.7301E-06

5.3021

D-( +)-Glucose

PubChemCID107526a

-Sugarb

8.5747E-06

9.6465E-06

5.0668

3-Methylinosine

PubChemCID126961054a

Others

9.8133E-06

1.0815E-05

5.0082

Furamizole

C14304

Others

0.0001501

0.0001609

3.8236

Gluconic acid

C00257

- Pentose phosphate pathway and Carbon metabolism

0.00015196

0.0001609

3.8183

D-Glucaric acid

C00818

- Ascorbate and aldarate metabolism and Cell wall precursor/ sugar acida

0.00096612

0.00098435

3.015

Hexose

C00738

-Cellular hexose transportb

0.0010293

0.0010293

2.9874

  1. aPubChem CID; PubChem (https://pubchem.ncbi.nlm.nih.gov/), National Center for Biotechnology Information (2022). PubChem Patent Summary for CN-107849574-B. Retrieved August 27, 2022 from https://pubchem.ncbi.nlm.nih.gov/patent/CN-107849574-B
  2. bHMDB ID; Wishart DS, Tzur D, Knox C, et al., HMDB: the Human Metabolome Database. Nucleic Acids Res. 2007 Jan;35(Database issue):D521-6. 17,202,168 (https://hmdb.ca/)
  3. cDrapal M., Barros de Carvalho E., Ovalle Rivera T. M., Becerra Lopez-Lavalle L. A., and Fraser P. D., 2019. Capturing Biochemical Diversity in Cassava (Manihot esculenta Crantz) through the Application of Metabolite Profiling. Journal of Agricultural and Food Chemistry 2019 67 (3), 986–993. https://doi.org/10.1021/acs.jafc.8b04769
  4. dHori H. Methylated nucleosides in tRNA and tRNA methyltransferases. Front Genet. 2014 May 23;5:144. https://doi.org/10.3389/fgene.2014.00144. PMID: 24,904,644; PMCID: PMC4033218