Table 1 85 differential compounds (healthy vs SLCMV-infected groups) identified by UHPLC-HRMS/MS and annotated in KEGG pathway analysis. Total is the total number of detected compounds which matched in the pathway; Hits is the number of differential compounds in the pathway; Raw P is the original P value calculated in the enrichment analysis; Holm P is the P value adjusted by the Holm-Bonferroni method; FDR P is the P value adjusted using the false discovery rate; Impact is the pathway impact value calculated using pathway topology analysis

Aminoacyl-tRNA biosynthesis

map00970

46

10

9.7818E-08

9.3905E-06

9.3905E-06

0.11111

Flavone and flavonol biosynthesis

map00944

10

3

0.0017776

0.16887

0.068052

0.7

Valine, leucine and isoleucine biosynthesis

map00290

22

4

0.0021266

0.1999

0.068052

0

Glyoxylate and dicarboxylate metabolism

map00630

29

4

0.0060453

0.56222

0.14509

0.0781

Alanine, aspartate and glutamate metabolism

map00250

22

3

0.018329

1

0.35191

0.32374

Flavonoid biosynthesis

map00941

47

4

0.032308

1

0.51693

0.00425

Cyanoamino acid metabolism

ko00460

29

3

0.038316

1

0.52548

0

Glycine, serine and threonine metabolism

map00260

33

3

0.053238

1

0.60842

0.30168

Sulfur metabolism

map00920

15

2

0.057039

1

0.60842

0.03315

Valine, leucine and isoleucine degradation

map00280

37

3

0.07057

1

0.62395

0

Butanoate metabolism

map00650

17

2

0.071494

1

0.62395

0

Glucosinolate biosynthesis

map00966

65

4

0.087535

1

0.70028

0

Citrate cycle (TCA cycle)

map00020

20

2

0.095105

1

0.70231

0.15581

Phenylalanine, tyrosine and tryptophan biosynthesis

map00400

22

2

0.11193

1

0.74948

0.02152

Phenylpropanoid biosynthesis

map00940

46

3

0.11745

1

0.74948

0.07013

Biosynthesis of secondary metabolites—unclassified

map01110

5

1

0.12491

1

0.74948

1

Glutathione metabolism

map00480

26

2

0.14761

1

0.78936

0.06248

Isoquinoline alkaloid biosynthesis

map00950

6

1

0.148

1

0.78936

0.5

Tropane, piperidine and pyridine alkaloid biosynthesis

map00960

8

1

0.19242

1

0.97222

0

Arginine and proline metabolism

map00330

34

2

0.22424

1

1

0.07781

Phenylalanine metabolism

map00360

11

1

0.25484

1

1

0.47059

Ubiquinone and other terpenoid-quinone biosynthesis

map00130

38

2

0.26382

1

1

0.00097

Nitrogen metabolism

map00910

12

1

0.27458

1

1

0

Histidine metabolism

map00340

15

1

0.3308

1

1

0.04264

Tyrosine metabolism

map00350

16

1

0.34858

1

1

0.10811

Sphingolipid metabolism

map00600

17

1

0.3659

1

1

0

Ascorbate and aldarate metabolism

map00053

18

1

0.38277

1

1

0

Lysine degradation

map00310

18

1

0.38277

1

1

0

Arginine biosynthesis

map00220

18

1

0.38277

1

1

0.08544

Pentose phosphate pathway

map00030

19

1

0.3992

1

1

0

Propanoate metabolism

map00640

20

1

0.4152

1

1

0

Zeatin biosynthesis

map00908

21

1

0.43079

1

1

0

Starch and sucrose metabolism

map00500

22

1

0.44598

1

1

0.13619

Pantothenate and CoA biosynthesis

map00770

23

1

0.46077

1

1

0

Purine metabolism

map00230

63

2

0.50037

1

1

0.00126

Galactose metabolism

map00052

27

1

0.51617

1

1

0

Inositol phosphate metabolism

map00562

28

1

0.52913

1

1

0

Glycerophospholipid metabolism

map00564

37

1

0.63153

1

1

0.03075

Cysteine and methionine metabolism

map00270

46

1

0.7121

1

1

0

Porphyrin and chlorophyll metabolism

map00860

48

1

0.72752

1

1

0