Figure 1

The chemical structures of scopoletin and scopolin and their biosynthetic pathway in Arabidopsis thaliana . Cloned and characterized genes encoding enzymes for scopoletin and scopolin biosynthesis are shown. The corresponding references [15],[34]-[42] are listed in the Reference section. The isoenzymes indicated by an asterisk (*) were functionally annotated by the in-house Ensemble Enzyme Prediction Pipeline (E2P2, version 2.0) (Plant Metabolic Network, http://pmn.plantcyc.org/ARA). The presented molecules were created using https://www.emolecules.com/ website. (4CL1) 4-coumarate:CoA ligase 1. (4CL2) 4-coumarate:CoA ligase 2. (4CL3) 4-coumarate:CoA ligase 3. (4CL5) 4-coumarate:CoA ligase 5. (C3H) p-coumaroyl 3'-hydroxylase. (CCoAOMT1) caffeoyl coenzyme A dependent O-methyltransferase 1. (CCoAOMT7) caffeoyl coenzyme A dependent O-methyltransferase 7. (F6'H1) feruloyl-CoA 6'-hydroxylase 1. (F6'H2) feruloyl-CoA 6'-hydroxylase 2. (HCT) shikimate O-hydroxycinnamoyltransferase. (OMT1) caffeate O-methyltransferase 1. (TSM1) tapetum-specific O- methyltransferase.