LD plot, haplotype blocks and V vDXS gene structure. The upper portion of the figure shows the LD plot based on r2 values and the haplotype structure (ten blocks) for the 102 polymorphic sites identified in VvDXS. Non-synonymous mutations are located in the LD plot. All the polymorphisms detected in coding regions are positioned on (a) VvDXS gene structure (exons = boxes) and (b) the functional domains of DXS protein (conserved domain database, CDD http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml). § = Non-neutral mutations predicted by SIFT.