Fig. 5
From: Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana
Proposed working model showing the miRNA response to DNA repair intermediates. The FPG-mediated BER pathway initiated under oxidative stress, generating blocked 3′-P end repair intermediates. In WT plants, ZDP and APE2 converted 3′-P end to 3′-OH end to allow subsequent progress in base repair. In zdp/ape2 mutant, 3′-P blocked repair intermediates accumulate and lead to the inhibition of MIR transcription, which causes reduced accumulation of pri-miRNAs and miRNAs. The starburst indicates an oxidized base