Fig. 4

Correlation analysis between metabolites and transcripts. A Histogram of the KEGG pathway enriched by the differentially expressed genes and metabolites between CLH and CLL. The ordinate represents the pathway name, and the abscissa represents the pathway to impact. B Assess the intrinsic correlation between the metabolites and transcripts by the two-way orthogonal partial least squares (O2PLS) method. Solid blue squares represent genes and solid green dots represent metabolites. The abscissa and ordinate represent the combined loading value, each gene/metabolite has a relative coordinate point in pq1 and pq2, p represents the loading value of the gene, and q represents the loading value of the metabolite. C The top15 differential expresses gene and differential metabolite loading histogram. Blue bars represent genes and green bars represent metabolites. The abscissa represents the combined loading value pq1, and the ordinate represents the differential metabolite/differential gene