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Table 1 Genome-context information suggesting functional links between YbhB homologs and various enzymes of biosynthesis and salvage of small molecules

From: Florigen and its homologs of FT/CETS/PEBP/RKIP/YbhB family may be the enzymes of small molecule metabolism: review of the evidence

Type of contextual evidence

Functionally linked proteins / domains / COGs

Taxa in which these functions are putatively linked

COG functional categories / Most relevant GO terms // Additional comments

Domain fusions

Glucose-sorbosone dehydrogenase, (Pectate Lyase-like carbohydrate-binding module, FN3-like domain) (COG1881, COG2133)

Actinobacteria, Gammaproteobacteria

Carbohydrate transport and metabolism / Hydrolase activity, acting on glycosyl bonds

Operons

Dialkylmaleic anhydride synthesis and conjugation module of tautomycin/tautomycetin biosynthesis operon

Actinobacteria

// Five-carbon substrate (a pentose?)

Phyletic vectors (prokaryotes)

Acyl-CoA synthetase, NDP forming (COG1042).

220 species

Energy production and conversion / ATP-binding, N-acetyltransferase activity // Nucleoside-containg substrate and product

Phyletic vectors (prokaryotes)

YbaR/Trm112 activator of RNA and protein methyltransferases; COG2835

233 species

Translation, ribosomal structure and genesis // RNA modification

Phyletic vectors (eukaryotes)

NUDT3 and other NUDIX hydrolases

Mammalia

// Hydrolases preferring pyrophosphate-containing substrates (nucleoside phosphates or phospholipids)

Shared putative regulatory motifs

RlmA 23S rRNA m(1)G745 methyltransferase (COG2226)

Enterobacteriaceae

Coenzyme transport and metabolism / rRNA base methylation

Shared putative regulatory motifs

YobB putative carbon-nitrogen hydrolase family protein (COG0388)

Enterobacteriaceae

Energy production and conversion / Nitrogen compound metabolic process

Shared putative regulatory motifs

AdrB c-di-GMP phosphodiesterase (COG2200)

Enterobacteriaceae

Signal transduction mechanisms / Cellular response to DNA damage stimulus // Nucleoside substrate

Integrated evidence

RlhA 23S rRNA 5-hydroxycytidine C2501 synthase (COG0826)

n/a

Signal transduction mechanisms / rRNA processing, rRNA modification

  1. See text for a more detailed characterization of each putative functional link