Table 2 Description of entities and corresponding tables in PINIR
From: PINIR: a comprehensive information resource for Pin-II type protease inhibitors
Entity | Table Name | Content |
|---|---|---|
Pin-II PIs | MST_PI_GENERAL_FEATURES | Stores general information about properties and composition of Pin-II PIs such as its Uniprot Accession number, Protein Name, Organism, Gene Name etc |
Taxonomy | MST_TAXONOMY | Stores organism’s details to which Pin- II PIs belongs to. It is captured from Uniprot database |
Sequence Domains | DET_SEQUENCE_DOMAINS | Captures the PIs and Domains relationship. Stores information about what Domains are found in a PI sequence |
Domains | MST_DOMAINS | Stores the information about Inhibitory Repeat Domains (IRD) sequences of the Pin–II PI. It includes the IRD sequence, Domain Type and the RCL and Linker sequences found in it |
Domain Type | MST_DOMAIN_TYPE | Based upon Linker organization in IRD sequences, stores the various Domain Types: Type 1 (H–L Type), Type 2 (L–H Type) and Type 3 (H + L Type) |
Reactive Loops | MST_REACTIVE_LOOPS | Stores the information about Reactive center loop (Active site loop) appearing in a domain. It includes the Target Protease found and Residues at P1, P2 and P1` position |
Target Protease | MST_TARGET_PROTEASE | Stores the Probable target protease for the Pin-II inhibitory domain. These are categorized as: Trypsin; Chymotrypsin; Elastase; and Unknown |
Linkers | MST_LINKERS | Stores the information about various Linker Sequences appearing between two domains in a Pin-II type PI. It includes the Linker sequence and type |
Cross References | DET_CROSS_REFERENCES | Stores details about other databases which capture information related to PINIR entries |
Domain Biochemical Properties | DET_DOMAIN_BIOCHEMICAL_PROPERTIES | Captures Inhibitory potential of an IRD |
Domain Biophysical Properties | DET_DOMAIN_BIOPHYSICAL_PROPERTIES | Captures Biophysical binding parameters for IRD and protease |
Domain Disulfide Bonds | DET_DOMAIN_DISULFIDE_BONDS | Captures the occurrence and position of disulfide bonds in a domain |
Iso-Electric Points | DET_ISO-ELECTRIC_POINTS | Captures the Isoelectric points details of the Pin-II type PI sequences, which is the pH at which a particular molecule carries no net electrical charge |
Gene Ontology | DET_PI_GENE_ONTOLOGY | Stores the lists of selected terms derived from the GO project, which gives the Functional attributes of Pin-II type PI |
Gene Ontology Type | MST_GENE_ONTOLOGY_TYPE | Stores the three categories of Gene Ontology: Cellular Component; Biological Process; and Molecular Function |
Signal Peptide | DET_SIGNAL_PEPTIDE | Captures the localization signal for the Pin-II type PI sequences |
Spatio Temporal Distribution | DET_SPATIO_TEMPORAL_DISTRIBUTION | Captures the localization and tissue specific occurrence of Pin-II type PI |
Publication | MST_PUBLICATION | This table stores the information related to references to publications related to PINIR entries |
Amino Composition | DET_AMINO_COMPOSITION | It stores the information about Amino Acids composition of Pin-II type PI and Domain sequences, which includes the percentage and number of an amino acid present in a sequence |