Fig. 6

Expression profile and transcriptional regulatory network in the brown and blue modules. a, d Scatterplots of gene significance versus module membership for the brown/S4 (a) and blue module/R4 (d), with correlations and p-values indicated. b, e Heat map of genes in the brown (b) and blue module (e). Red indicates high expression, blue indicates low expression. The color scale represents Z-score. c, f GO analysis of genes in the brown (c) and blue module (f). Each circle represents an enrichment category, and the size of the circle indicates the number of genes. Detailed enrichment results are shown in Table S6 and S7. g, h KEGG analysis of genes in the brown (g, top 20) and blue module (h, corrected p-value < 0.05). i, j Coexpression network of the brown module (i) and blue module (j). The ellipses of the outer circle represent the hub genes, the arrows in the inner circle represent transcription factors, and the small dots in the circles represent other coexpressed genes in each module. The relationships of all the genes are connected by lines, the line color represents the weight. The red ellipse /arrow/dot indicates up-regulated (log2(R/S) > 1) and the blue ellipse /arrow/dot indicates down-regulated in the resistance line (log2(R/S) < − 1) at the T4 stage