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Fig. 9 | BMC Plant Biology

Fig. 9

From: Knockout of the entire family of AITR genes in Arabidopsis leads to enhanced drought and salinity tolerance without fitness costs

Fig. 9

A model of action of AITRs in ABA and abiotic stress response. In the absent of ABA, PP2C phosphatases bind and deactivate SnRK2 kinases. Environmental stimuli and developmental cues promote ABA biosynthesis. ABA binds to PYR/PYL/RCAR receptors and suppresses the activity of PP2Cs. SnRK2s thus become activated, and they, in turn, phosphorylate down-stream transcription factors (TFs), resulting in the activation or repression of their target genes, including PP2Cs, PYR/PYL/RCARs and AITRs. Activation of PP2Cs and repression of PYR/PYL/RCARs represent negative feedback regulatory loops. AITRs regulate the expression of PP2Cs and PYR/PYL/RCARs, therefore function as feed back regulators in ABA signaling and abiotic stress responses

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