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Table 2 Response Surface Regression (coded units) and Analysis of Variance (ANOVA) for colchicine compound

From: Screening the elite chemotypes of Gloriosa superba L. in India for the production of anticancer colchicine: simultaneous microwave-assisted extraction and HPTLC studies

Term

Coef

SE Coef

Sum of Squares

dF

Mean Square

F-value

p-value

Constant

7.37333

0.01560

9.3700

14

0.6695

917.01

< 0.0001*

A

0.19092

0.00780

0.4374

1

0.4374

599.06

< 0.0001*

B

0.20350

0.00780

0.4969

1

0.4969

680.63

< 0.0001*

C

−0.04550

0.00780

0.0248

1

0.0248

34.03

< 0.0001*

D

−0.46208

0.00780

2.5600

1

2.5600

3509.30

< 0.0001*

AB

−0.05875

0.01351

0.0138

1

0.0138

18.91

0.0009*

AC

0.00500

0.01351

0.0001

1

0.0001

0.13

0.7178

AD

−0.09100

0.01351

0.0331

1

0.0331

45.37

< 0.0001*

BC

0.01375

0.01351

0.0008

1

0.0008

1.04

0.3289

BD

0.16700

0.01351

0.1116

1

0.1116

152.79

< 0.0001*

CD

−0.07775

0.01351

0.0242

1

0.0242

33.12

< 0.0001*

A2

−0.95550

0.01170

4.8700

1

4.8700

6668.97

< 0.0001*

B2

−0.59338

0.01170

1.8800

1

1.8800

2571.91

< 0.0001*

C2

−0.41538

0.01170

0.9202

1

0.9202

1260.31

< 0.0001*

D2

−0.61900

0.01170

2.0400

1

2.0400

2798.84

< 0.0001*

Residual

  

0.0088

12

0.0007

  

Lack of Fit

  

0.0063

10

0.0006

0.5104

0.8086

Pure Error

  

0.0025

2

0.0012

  

Cor Total

  

9.3800

26

   
  1. A-Microwave power; B-Irradiation Time; C-Solvent composition; D-pH
  2. Coef Regression Coefficients, SE Coef Standard Error of Regression Coefficient, Df Degree of Freedom
  3. *Very significant, where p < 0.01