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Fig. 6 | BMC Plant Biology

Fig. 6

From: Crystal structure of DRIK1, a stress-responsive receptor-like pseudokinase, reveals the molecular basis for the absence of ATP binding

Fig. 6

Cocrystal structure of ZmDRIK1-KD bound with ENMD-2076 at the ATP binding pocket. a Cartoon representation of the cocrystal structure of ZmDRIK1-KD bound with ENMD-2076. Protein features are colored as follows: glycine-rich (P-)loop - cyan; hinge region - yellow; catalytic loop -pink; DLE (more commonly DFG) motif - blue; activation segment - orange; C-helix – purple. Other protein regions are in green. ENMD-2076 is shown in stick and colored as follows: carbon – green; nitrogen – blue. b and c Structural features of the ZmDRIK1-KD ATP binding pocket bound with ENMD-2076 (b) and apo form (c). Residues Leu240, Tyr363, Leu375, ENMD-2076 and the gatekeeper (Phe) are represented in sticks. The black dashed line (b) indicates an interaction between protein and ENMD-2076. d and e Surface representation of the cocrystal ZmDRIK1-KD-ENMD-2076

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BMC Plant Biology

ISSN: 1471-2229

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