Fig. 8

MT and MAGAP1-dependent symmetry breaking of plasma membrane-associated RAC1-RIPa signaling. a In absence of MTs or MAGAP1, GEF-supported RAC1 activity can freely diffuse at the plasma membrane and RIPa is evenly distributed. b In presence of intact MTs and functional MT-associated MAGAP1, MAGAP1 laterally inhibits RAC1 activity from MTs. This leads to spatially restricted negative feedback, and hence symmetry breaking and membrane heterogeneity