Table 2 GO analysis of the most significant up- and downregulated DEGs (FDR < 0.05)

D1

GO:0140098

catalytic activity, acting on RNA

2.76E-05

137

GO:0004672

protein kinase activity

4.48E-38

492

GO:0008168

methyltransferase activity

0.0098431

56

GO:0006468

protein phosphorylation

6.47E-38

484

GO:0016741

transferase activity, transferring one-carbon groups

0.0098431

61

GO:0016773

phosphotransferase activity, alcohol group as acceptor

2.61E-33

511

GO:0006801

superoxide metabolic process

0.011936

10

GO:0016301

kinase activity

6.61E-31

521

GO:0004719

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

0.011936

16

GO:0016310

phosphorylation

1.33E-30

501

D2

GO:0005975

carbohydrate metabolic process

0.031471

366

GO:0008219

cell death

1.29E-13

352

GO:0008144

drug binding

1.29E-13

1615

GO:0006915

apoptotic process

2.19E-13

336

GO:0012501

programmed cell death

2.19E-13

336

GO:0005524

ATP binding

2.21E-13

1593

R1

GO:0003735

structural constituent of ribosome

1.80E-14

229

GO:0005975

carbohydrate metabolic process

6.27E-08

209

GO:0005840

ribosome

1.80E-14

229

GO:0004194

obsolete pepsin A activity

1.03E-07

37

GO:1990904

ribonucleoprotein complex

6.26E-11

242

GO:0044262

cellular carbohydrate metabolic process

8.70E-07

71

GO:0005198

structural molecule activity

4.53E-09

273

GO:0016798

hydrolase activity, acting on glycosyl bonds

8.57E-06

106

GO:0006518

peptide metabolic process

1.34E-07

279

GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

2.33E-05

102

R2

GO:0003735

structural constituent of ribosome

9.55E-28

316

GO:0008144

drug binding

4.30E-42

1102

GO:0005840

ribosome

9.55E-28

316

GO:0005524

ATP binding

4.30E-42

1092

GO:0006412

translation

1.79E-24

402

GO:0030554

adenyl nucleotide binding

4.30E-42

1094

GO:0006518

peptide metabolic process

3.43E-24

404

GO:0032559

adenyl ribonucleotide binding

4.30E-42

1094

GO:0043043

peptide biosynthetic process

3.43E-24

404

GO:0006468

protein phosphorylation

9.13E-41

618

R3

GO:0003700

DNA-binding transcription factor activity

2.68E-05

109

GO:0003735

structural constituent of ribosome

2.54E-18

216

GO:0140110

transcription regulator activity

0.00017175

109

GO:0005840

ribosome

2.54E-18

216

GO:0016759

cellulose synthase activity

0.00061948

16

GO:0044267

cellular protein metabolic process

2.38E-17

583

GO:0016760

cellulose synthase (UDP-forming) activity

0.00061948

16

GO:1990904

ribonucleoprotein complex

8.79E-16

230

GO:0030243

cellulose metabolic process

0.00061948

16

GO:0043228

non-membrane-bounded organelle

1.38E-13

260