Table 2 Fold changes of the metabolites involved in 18 pathways identified as being significantly enriched in the KEGG analysis. “/” indicates that the metabolite or a significant difference was not detected
Metabolites | Subclass | Within-phase comparisons | Between-phase comparisons | |||||
|---|---|---|---|---|---|---|---|---|
WD_1 vs WW_1 | WD_2 vs WW_2 | WD_3 vs WW_3 | WD_2 vs WD_1 | WD_3 vs WD_2 | WW_2 vs WW_1 | WW_3 vs WW_2 | ||
Nonmetal oxoanionic compounds | ||||||||
Phosphoric acid | Nonmetal phosphates | 0.4766 | 0.4204 | / | / | / | 0.7124 | / |
Sulfate | Nonmetal sulfates | 0.6713 | 0.6650 | 0.7656 | / | / | / | 0.8236 |
Fatty acyls | ||||||||
13-oxo-octadecadienoic acid | Linoleic acids and derivatives | / | / | / | / | / | / | 0.4233 |
13S-hydroxy-octadecadienoic acid | Linoleic acids and derivatives | / | / | / | / | / | / | 0.4576 |
20-hydroxy-leukotriene B4 | Eicosanoids | / | / | / | / | / | / | 0.4847 |
9,10-dihydroxy-12-octadec-enoic acid | Fatty acids and conjugates | 1.4183 | / | / | 0.7178 | / | / | 0.5667 |
9,12,13-trihydroxy-octadec-10-enoic acid | Fatty acids and conjugates | 1.4510 | / | 2.0848 | / | / | 1.5159 | 0.3778 |
9S,11R,15S-trihydroxy-2,3-dinor-13E-prostaenoic acid-cyclo[8S,12R] | Eicosanoids | / | / | 1.6657 | / | / | / | 0.4795 |
Alpha-linolenic acid | Linoleic acids and derivatives | / | / | / | / | / | / | 0.4510 |
Arachidonic acid (d8) | Fatty acids and conjugates | / | / | / | 1.9797 | 0.5671 | / | 0.2218 |
Norlinolenic acid | Fatty acids and conjugates | 0.5674 | / | 1.8503 | 1.7476 | / | / | 0.3516 |
Traumatic acid | Fatty acids and conjugates | 0.5335 | 0.5854 | / | / | / | / | 0.6102 |
Traumatin | Fatty acids and conjugates | / | / | 3.3487 | / | / | / | 0.1040 |
Glycerophospholipids | ||||||||
Lysophosphatidylcholine(16:0) | Glycerophosphocholines | / | / | / | / | / | 2.1402 | / |
Phosphatidyl alcohol(16:0/18:2(9Z,12Z)) | Glycerophosphates | 0.7050 | 0.6145 | / | / | / | / | 0.6955 |
Phosphatidyl ethanolamine(16:1(9Z)/P-18:1(11Z)) | Glycerophosphoethanolamines | 0.6389 | 0.6606 | / | / | / | / | 0.6178 |
Phosphatidyl ethanolamine(18:3(6Z,9Z,12Z)/P-18:0) | Glycerophosphoethanolamines | / | / | / | / | / | 1.3388 | 0.6226 |
Steroids and steroid derivatives | ||||||||
Campesterol | Ergostane steroids | 0.5078 | 0.5925 | / | / | / | / | / |
Cholesterol ester(20:1(11Z)) | Steroid esters | / | 0.4889 | 0.4198 | / | / | / | / |
Carboxylic acids and derivatives | ||||||||
L-arginine | Amino acids, peptides, and analogues | / | / | / | / | / | / | 0.1530 |
L-aspartic acid | Amino acids, peptides, and analogues | / | / | / | 2.4269 | / | / | 0.2733 |
L-cystathionine | Amino acids, peptides, and analogues | 0.4052 | / | 0.2932 | / | / | 0.4034 | 3.2124 |
Organooxygen compounds | ||||||||
D-glucose | Carbohydrates and carbohydrate conjugates | / | / | / | 1.3310 | / | 1.2303 | / |
D-maltose | Carbohydrates and carbohydrate conjugates | / | / | / | 1.1766 | / | / | / |
Fructose 6-phosphate | Carbohydrates and carbohydrate conjugates | 0.5245 | 0.4511 | / | / | / | / | 0.6804 |
Maltotriose | Carbohydrates and carbohydrate conjugates | 0.4487 | 0.7361 | 0.5299 | / | / | 0.5619 | 1.7477 |
Raffinose | Carbohydrates and carbohydrate conjugates | 0.4885 | / | 0.7346 | 1.6008 | / | / | 1.2806 |
Indoles and derivatives | ||||||||
Indoleacetic acid | Indolyl carboxylic acids and derivatives | / | 0.6223 | / | / | / | 1.5008 | / |
5-methoxytryptamine | Tryptamines and derivatives | / | 0.6575 | / | / | / | / | 0.4630 |
Others | ||||||||
Alpha-dimorphecolic | Others | / | / | / | / | / | / | 0.3647 |