Table 2 The arrangement of all possible events explaining the sixteen four-bit binary MSAP codes
Code | Demethylation (DM) | De novo methylation (DNM) | Methylation State Preservation (MSP) | Non-methylation State Preservation (NMSP) | Methylation (M = DNMÂ +Â MSP) | Non-methylation (NM = DMÂ +Â NMSP) | De novo methylation of CHG type (DNM-CHG) | De novo methylation of CG type (DNM-CG) | Demethylation of CHG type (DM-CHG) | Demethylation of CG type (DM-CG) |
|---|---|---|---|---|---|---|---|---|---|---|
0000 | 2 | 2 | 10 | 2 | 12 | 4 | 0 | 2 | 0 | 2 |
0001 | 9 | 3 | 3 | 1 | 6 | 10 | 0 | 3 | 8 | 1 |
0010 | 4 | 0 | 2 | 2 | 2 | 6 | 0 | 0 | 2 | 2 |
0011 | 6 | 0 | 0 | 2 | 0 | 8 | 0 | 0 | 4 | 2 |
0100 | 3 | 9 | 3 | 1 | 12 | 4 | 8 | 1 | 0 | 3 |
0101 | 1 | 1 | 5 | 9 | 6 | 10 | 0 | 1 | 0 | 1 |
0110 | 3 | 2 | 0 | 3 | 2 | 6 | 3 | 0 | 0 | 3 |
0111 | 3 | 0 | 0 | 5 | 0 | 8 | 0 | 0 | 0 | 3 |
1000 | 0 | 4 | 2 | 2 | 6 | 2 | 1 | 2 | 0 | 0 |
1001 | 2 | 3 | 0 | 3 | 3 | 6 | 2 | 3 | 2 | 0 |
1010 | 0 | 0 | 1 | 3 | 0 | 3 | 0 | 0 | 0 | 0 |
1011 | 1 | 0 | 0 | 3 | 0 | 4 | 0 | 0 | 1 | 0 |
1100 | 0 | 6 | 0 | 2 | 6 | 2 | 4 | 2 | 0 | 0 |
1101 | 0 | 3 | 0 | 5 | 3 | 5 | 0 | 3 | 0 | 0 |
1110 | 0 | 1 | 0 | 3 | 1 | 3 | 1 | 0 | 0 | 0 |
1111 | 0 | 0 | 0 | 4 | 0 | 4 | 0 | 0 | 0 | 0 |