TY - JOUR AU - Shao, Mon-Ray AU - Kumar Kenchanmane Raju, Sunil AU - Laurie, John D. AU - Sanchez, Robersy AU - Mackenzie, Sally A. PY - 2017 DA - 2017/02/20 TI - Stress-responsive pathways and small RNA changes distinguish variable developmental phenotypes caused by MSH1 loss JO - BMC Plant Biology SP - 47 VL - 17 IS - 1 AB - Proper regulation of nuclear-encoded, organelle-targeted genes is crucial for plastid and mitochondrial function. Among these genes, MutS Homolog 1 (MSH1) is notable for generating an assortment of mutant phenotypes with varying degrees of penetrance and pleiotropy. Stronger phenotypes have been connected to stress tolerance and epigenetic changes, and in Arabidopsis T-DNA mutants, two generations of homozygosity with the msh1 insertion are required before severe phenotypes begin to emerge. These observations prompted us to examine how msh1 mutants contrast according to generation and phenotype by profiling their respective transcriptomes and small RNA populations. SN - 1471-2229 UR - https://doi.org/10.1186/s12870-017-0996-4 DO - 10.1186/s12870-017-0996-4 ID - Shao2017 ER -