Fig. 4

Multiple sequence alignment of CML protein sequences. The sequence alignment shows presence of the D-x-D-x-D motif in the fourth EF-hand. The D-x-D-x-D motif was conserved at 14^th, 16^th, and 18^th position. In addition to the presence of a conserved D-x-D-x-D motif, CML also found to contain several conserved D and E amino acids in other EF-hands. The multiple sequence alignment was conducted using the Multalin software