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Table 1 Human DAMPs

From: DAMPs, MAMPs, and NAMPs in plant innate immunity

DAMP Receptor Interactor Reference
High Mobility Group Box 1 (HMGB1) CXCR4 a CXCL12 b [14]
TLR4 c CD14 d/MD-2 e [15, 63]
TLR4 LPS f [64, 65]
TLR3/7/9 Nucleic acids [66, 67]
IL-1R1 g IL-1α/β h [68]
TLR2 Nucleosome [69]
CD163 i Haptoglobin [70]
RAGE j   [66, 71]
Siglec-10 k CD24 [72]
TIM3 l   [73]
Heat Shock Protein (HSP) TLR2/4 CD14 [7477]
β-defensin TLR4   [74, 78]
Peroxiredoxin-2 (PRDX2)    [79]
Calreticulin CD91   [80, 81]
14-3-3η    [8285]
Purines Adenosine P1   [86, 87]
ADP P2Y   [8689]
ATP P2X/P2Y   [86, 87, 9093]
Pyrimidines UDP P2Y   [86, 87, 94]
UDP-glucose P2Y   [86, 87, 95]
Amyloid β TLR4/6 CD36 [74, 96]
RAGE   [9799]
FPRL1 m   [100]
NLRP3 n   [101]
S100/calgranulin RAGE   [102]
TLR4   [103]
Uric acid TLR2/4 CD14 [104, 105]
NLRP3   [106]
Degradation product of ECM o Biglycan TLR2/4   [107, 108]
Hyaluronan TLR2/4 CD44/MD-2 [30, 109111]
Versican TLR2/6 CD14/MD-2 [112]
Extra-domain A of fibronectin TLR4   [113]
Surfactant protein A TLR2   [114, 115]
Oxidized LDL p TLR4/6 CD36 [74, 116, 117]
TLR4   [118]
SR q   [119]
Oxidized phospholipids PPARα r   [120, 121]
TLR2/4 CD14/MD-2 [121124]
mitochondrial DAMPs DNA (unmethylated CpG) TLR9   [125]
ATP P2X/P2Y   [86, 87, 9093]
TFAM s    [126]
N-formyl peptides FPRs t   [127]
Succinate    [128]
Cardiolipin NLRP3   [129]
  1. a CXCR4: chemokine (C-X-C motif) receptor 4; b CXCL12: chemokine (C-X-C motif) ligand 12; c TLR: toll-like receptor; d CD: cell differentiation antigen; e MD-2: myeloid differentiation protein-2; f LPS: lipopolysaccharides; g IL-1R1: interleukin 1 receptor, type I; h IL: interleukin; i CD163: cluster of differentiation 163; j RAGE: receptor for advanced glycation end products; k Siglec-10: sialic acid binding Ig-like lectin -10; l TIM3: T-cell immunoglobulin mucin receptor 3; m FPRL1: formyl peptide receptor-like 1; n NLRP: NOD-like receptor protein; o ECM: extracellular matrix components; p LDL: low density lipoprotein; q SR: Scavenger Receptor; r PPARα: peroxisome proliferator-activated receptor alpha; s TFAM: mitochondrial transcription factor A; t FPRs: formyl peptide receptors