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Table 1 Structure-based sequence alignment of CDKs for the chemical-genetic approach

From: Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN-DEPENDENT KINASE A;1

Kinase

ß-sheets

ß2

ß3

ß4

ß5

Cdk1 (H.s.)

V

V

Y

V

A

M

K

K

I

V

S

Y

L

I

F 80

Cdk2 (H.s.)

V

V

Y

V

A

L

K

K

I

V

K

Y

L

V

F 80

Cdk3 (H.s.)

V

V

Y

V

A

L

K

K

I

V

R

Y

L

V

F 80

Cdc2 (S.p.)

V

V

Y

V

A

M

K

K

C

V

R

Y

L

V

F 84

CDC28 (S.c.)

V

V

Y

V

A

L

K

K

I

V

R

Y

L

V

F 88

CDKA;1 (A.t.)

V

V

Y

I

A

L

K

K

I

V

K

Y

L

V

F 80

  1. Homo sapiens (H.s.), Schizosaccharomyces pombe (S.p.), Saccharomyces cerevisiae (S.c.), Arabisopsis thaliana (A.t.). Bold letters mark residues contacting ATP in the active site. Numbers indicate the positions of the respective residues in the protein. The “gatekeeper” positions are numbered
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BMC Plant Biology

ISSN: 1471-2229

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