Fig. 2

Hierarchical clustering of gene expression profiles in control and HP cells showing significant (p ≤ 0.05) differences between the two lines on different days of analysis. Heat map scale indicates spot intensities after local background subtraction. Blue indicates low-intensity spots while Red indicates spots with high signal. As expected, day 3 and day 5 controls appear similar to one another, as do the day 3 and day 5 HP cells. Transcripts were clustered into 8 distinct groups (1–8) based on co-regulation of gene expression patterns that were significantly up or down regulated on both day 3 and day 5 as compared to controls cells