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Table 3 Power of association tests at markers linked to causal polymorphims according to LD extent in the association panel, heritability and effect of causal polymorphism (% of trait variance explained)

From: Genetic diversity, linkage disequilibrium and power of a large grapevine (Vitis vinifera L) diversity panel newly designed for association studies

r 2 VS a

Mean power at the marker linked to causal polymorphismb

h 2 = 0.5

h 2 = 0.7

h 2 = 0.9

effect = 10 %

effect = 25 %

effect = 10 %

effect = 25 %

effect = 10 %

effect = 25 %

1

0.9

6.0

3.4

22.4

22.9

69.6

0.1

0.1

0.6

0.3

2.2

2.3

7.0

0.15

0.1

0.9

0.5

3.4

3.4

10.4

0.2

0.2

1.2

0.7

4.5

4.6

13.9

0.25

0.2

1.5

0.9

5.6

5.7

17.4

0.3

0.3

1.8

1.0

6.7

6.9

20.9

0.35

0.3

2.1

1.2

7.8

8.0

24.4

0.4

0.4

2.4

1.4

8.9

9.2

27.8

0.45

0.4

2.7

1.6

10.1

10.3

31.3

  1. aSquared correlation between the causal polymorphism and the linked marker, corrected by kinship and structure
  2. bMean power over the 314 SNPs with MAF > 5 % in the four genomic regions, assuming a family wise error rate of 5 % and using AIS kinship estimation, calculated as the power at the causal locus multiplied by the corrected LD between the causal locus and the marker