|
r
2
VS
a
|
Mean power at the marker linked to causal polymorphismb
|
|---|
|
h
2 = 0.5
|
h
2 = 0.7
|
h
2 = 0.9
|
|---|
|
effect = 10 %
|
effect = 25 %
|
effect = 10 %
|
effect = 25 %
|
effect = 10 %
|
effect = 25 %
|
|---|
|
1
|
0.9
|
6.0
|
3.4
|
22.4
|
22.9
|
69.6
|
|
0.1
|
0.1
|
0.6
|
0.3
|
2.2
|
2.3
|
7.0
|
|
0.15
|
0.1
|
0.9
|
0.5
|
3.4
|
3.4
|
10.4
|
|
0.2
|
0.2
|
1.2
|
0.7
|
4.5
|
4.6
|
13.9
|
|
0.25
|
0.2
|
1.5
|
0.9
|
5.6
|
5.7
|
17.4
|
|
0.3
|
0.3
|
1.8
|
1.0
|
6.7
|
6.9
|
20.9
|
|
0.35
|
0.3
|
2.1
|
1.2
|
7.8
|
8.0
|
24.4
|
|
0.4
|
0.4
|
2.4
|
1.4
|
8.9
|
9.2
|
27.8
|
|
0.45
|
0.4
|
2.7
|
1.6
|
10.1
|
10.3
|
31.3
|
-
aSquared correlation between the causal polymorphism and the linked marker, corrected by kinship and structure
-
bMean power over the 314 SNPs with MAF > 5 % in the four genomic regions, assuming a family wise error rate of 5 % and using AIS kinship estimation, calculated as the power at the causal locus multiplied by the corrected LD between the causal locus and the marker
