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Fig. 8 | BMC Plant Biology

Fig. 8

From: Elevated growth temperature decreases levels of the PEX5 peroxisome-targeting signal receptor and ameliorates defects of Arabidopsis mutants with an impaired PEX4 ubiquitin-conjugating enzyme

Fig. 8

A working model for high-temperature amelioration of pex4-1 physiological defects. a In wild type, PEX5 recognizes and delivers PTS1 cargo into peroxisomes. The peroxisome-tethered ubiquitin conjugating enzyme (PEX4) and RING finger peroxins (PEX2, PEX10, PEX12) collaborate to ubiquitinate PEX5. Ubiquitinated PEX5 is recycled back to the cytosol by the PEX1-PEX6 ATPase complex. b At normal growth temperature (22 °C), mutations in PEX4 slow PEX5 recycling, resulting in elevated membrane-associated PEX5, which contributes to pex4 physiological defects. These defects are amplified by PEX5 overexpression, implying that these defects do not exclusively result from reduced matrix protein import. c At high temperature (28 °C), an unknown ubiquitination enzyme (question mark) promotes ubiquitin-dependent PEX5 degradation, reducing overall PEX5 levels and ameliorating pex4 defects

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BMC Plant Biology

ISSN: 1471-2229

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