Fig. 3

Phylogenetic trees of 5-FCL, DHC, and GDCH proteins. Phylogenetic trees of 5-FCL, DHC, and GDCH proteins from maize, sorghum, millet, rice, Arabidopsis, human, rat, mouse, yeast, and E. coli constructed by MEGA version 5 using neighbour-joining algorithms. Plant branches are divided into multiple classes. a, 5-FCL; b, DHC; c, GDCH. The accession numbers are: 5FCL SORBI (Swiss-Prot: C5XCF3), 5FCLL SORBI (C5YSM0), 5FCLL SETIT (K3Y8D4), 5FCL SETIT (K3ZVU5), 5FCLL-2 SETIT (K3YF41), 5FCL ORYSJ (Q0D564), 5FCLL ORYSJ (Q2QX67); 5FCL ARATH (Q8L539), 5FCLL ARATH (Q9SRE0), 5FCL ECOLI (P0AC28), FTHC YEAST (P40099), MTHFS HUMAN (P49914), MTHFS RAT (Q5M9F6), MTHFD RAT (M0R5E8), MTHSD MOUSE (Q3URQ7), MTHFS MOUSE (Q9D110); FOLD1 SORBI (C5X9V9), FOLD2 SORBI (C5Z052), FOLD3 SORBI (C5XT02), FOLD1 SETIT (K3ZU46), FOLD2 SETIT (K3Z8H6), FOLD3 SETIT (K3YTG4), FOLD1 ORYSJ (Q6K2P4), FOLD2 ORYSJ (B9FHE0), FOLD3 ORYSJ (Q0E4G1), FOLD1 ARATH (A2RVV7), FOLD2 ARATH (Q9LHH7), FOLD3 ARATH (O65269), FOLD4 ARATH (O65271), FOLD ECOLI (P24186), MTD2L HUMAN (Q9H903), MTDC HUMAN (P13995), MTD2L RAT (D3ZUA0), MTDC RAT (D4A1Y5), MTDC MOUSE (P18155), MTD2L MOUSE (D3YZG8); GCSH1 SORBI (C5YT80), GCSH2 SORBI (C5XW40), GCSH1 SETIT (K3YAF8), GCSH2 SETIT (K3YWB1), GCSH3 SETIT (K3ZA97), GCSH4 SETIT (K3YMG1), GCSH ORYSJ (A3C6G9), GCSH1 ARATH (P25855), GCSH2 ARATH (O82179), GCSH3 ARATH (Q9LQL0), GCSH ECOLI (P0A6T9), GCSH YEAST (P39726), GCSH HUMAN (P23434), GCSH RAT (Q5I0P2), GCSH-2 RAT (Q9QYU8), and GCSH MOUSE (Q91WK5)