Metabolic pathways | Metabolites | Relative concentration | Fold changes | ||||
---|---|---|---|---|---|---|---|
CK | SS | AS | log2 (SS/CK) | log2 (AS/CK) | log2 (AS/SS) | ||
TCA cycle | Cit | 70.05 | 114.56 | 166.40 | 0.71 | 1.25a | 0.54 |
Aco | 1.37 | 1.44 | 2.87 | 0.07 | 1.07a | 1.00a | |
α-KG | 0.15 | 0.27 | 0.59 | 0.81 | 1.94a | 1.13a | |
Succ | 17.80 | 11.37 | 86.02 | −0.65 | 2.27a | 2.92a | |
Fum | 1.25 | 1.04 | 7.21 | −0.27 | 2.53a | 2.80a | |
Mal | 10.44 | 16.43 | 18.29 | 0.65 | 0.81 | 0.15 | |
Glycolysis | Glc | 22.49 | 11.19 | 9.45 | −1.01a | −1.25a | −0.24 |
G6P | 0.49 | 0.23 | 0.10 | −1.09a | −2.32a | −1.23a | |
F6P | 0.19 | 0.10 | 0.05 | −0.95 | −1.96a | −1.01a | |
3-PGA | 0.44 | 0.27 | 0.14 | −0.72 | −1.63a | −0.92 | |
Pyr | 0.49 | 0.52 | 0.39 | 0.09 | −0.34 | −0.43 | |
PEP | 0.64 | 0.61 | 0.25 | −0.07 | −1.34a | −1.27a | |
Amino acids | Glu | 134.99 | 141.95 | 36.04 | 0.07 | −1.91a | −1.98a |
GABA | 104.32 | 46.87 | 33.20 | −1.15a | −1.65a | −0.50 | |
Ala | 151.29 | 98.92 | 14.73 | −0.61 | −3.36a | −2.75a | |
Asp | 12.33 | 7.44 | 7.28 | −0.73 | −0.76 | −0.03 | |
Gly | 7.45 | 4.09 | 0.97 | −0.87 | −2.94a | −2.07a | |
Thr | 9.71 | 4.95 | 1.50 | −0.97 | −2.70a | −1.7a2 | |
Ser | 16.05 | 11.41 | 2.22 | −0.49 | −2.85a | −2.36a | |
Val | 17.42 | 8.19 | 5.28 | −1.09a | −1.72a | −0.64 | |
Pro | 8.54 | 17.36 | 14.58 | 1.02a | 0.77 | −0.25 | |
Phe | 0.41 | 0.19 | 0.16 | −1.08a | −1.31a | −0.23 | |
Gln | 0.11 | 0.12 | 0.02 | 0.17 | −2.20a | −2.36 a | |
Ile | 7.50 | 3.06 | 2.51 | −1.29a | −1.58a | −0.29 | |
Leu | 0.63 | 0.19 | 0.14 | −1.73a | −2.18a | −0.44 | |
Asn | 16.66 | 3.07 | 1.29 | −2.44a | −3.69a | −1.25a | |
Sugars and polyols | Fru | 860.33 | 684.72 | 237.87 | −0.33 | −1.85a | −1.53a |
Suc | 96.20 | 180.38 | 104.07 | 0.91 | 0.11 | −0.79 | |
Tal | 119.04 | 85.27 | 26.98 | −0.48 | −2.14a | −1.66a | |
Kes | 60.63 | 84.66 | 24.67 | 0.48 | −1.30a | −1.78a | |
Hep | 0.80 | 0.29 | 0.18 | −1.47a | −2.19a | −0.72 | |
mIno | 11.07 | 24.44 | 4.62 | 1.14a | −1.26a | −2.40a | |
Sor | 9.78 | 3.13 | 3.42 | −1.65a | −1.52a | 0.13 | |
Rib | 9.02 | 5.24 | 1.56 | −0.78 | −2.53a | −1.75a | |
Gala | 0.85 | 3.22 | 0.84 | 1.92a | −0.02 | −1.94a | |
Raf | 0.39 | 1.01 | 0.10 | 1.39a | −1.91a | −3.29a |