Metabolic pathways
|
Metabolites
|
Relative concentration
|
Fold changes
|
---|
CK
|
SS
|
AS
|
log2
(SS/CK)
|
log2
(AS/CK)
|
log2
(AS/SS)
|
---|
TCA cycle
|
Cit
|
70.05
|
114.56
|
166.40
|
0.71
|
1.25a
|
0.54
|
Aco
|
1.37
|
1.44
|
2.87
|
0.07
|
1.07a
|
1.00a
|
α-KG
|
0.15
|
0.27
|
0.59
|
0.81
|
1.94a
|
1.13a
|
Succ
|
17.80
|
11.37
|
86.02
|
−0.65
|
2.27a
|
2.92a
|
Fum
|
1.25
|
1.04
|
7.21
|
−0.27
|
2.53a
|
2.80a
|
Mal
|
10.44
|
16.43
|
18.29
|
0.65
|
0.81
|
0.15
|
Glycolysis
|
Glc
|
22.49
|
11.19
|
9.45
|
−1.01a
|
−1.25a
|
−0.24
|
G6P
|
0.49
|
0.23
|
0.10
|
−1.09a
|
−2.32a
|
−1.23a
|
F6P
|
0.19
|
0.10
|
0.05
|
−0.95
|
−1.96a
|
−1.01a
|
3-PGA
|
0.44
|
0.27
|
0.14
|
−0.72
|
−1.63a
|
−0.92
|
Pyr
|
0.49
|
0.52
|
0.39
|
0.09
|
−0.34
|
−0.43
|
PEP
|
0.64
|
0.61
|
0.25
|
−0.07
|
−1.34a
|
−1.27a
|
Amino acids
|
Glu
|
134.99
|
141.95
|
36.04
|
0.07
|
−1.91a
|
−1.98a
|
GABA
|
104.32
|
46.87
|
33.20
|
−1.15a
|
−1.65a
|
−0.50
|
Ala
|
151.29
|
98.92
|
14.73
|
−0.61
|
−3.36a
|
−2.75a
|
Asp
|
12.33
|
7.44
|
7.28
|
−0.73
|
−0.76
|
−0.03
|
Gly
|
7.45
|
4.09
|
0.97
|
−0.87
|
−2.94a
|
−2.07a
|
Thr
|
9.71
|
4.95
|
1.50
|
−0.97
|
−2.70a
|
−1.7a2
|
Ser
|
16.05
|
11.41
|
2.22
|
−0.49
|
−2.85a
|
−2.36a
|
Val
|
17.42
|
8.19
|
5.28
|
−1.09a
|
−1.72a
|
−0.64
|
Pro
|
8.54
|
17.36
|
14.58
|
1.02a
|
0.77
|
−0.25
|
Phe
|
0.41
|
0.19
|
0.16
|
−1.08a
|
−1.31a
|
−0.23
|
Gln
|
0.11
|
0.12
|
0.02
|
0.17
|
−2.20a
|
−2.36 a
|
Ile
|
7.50
|
3.06
|
2.51
|
−1.29a
|
−1.58a
|
−0.29
|
Leu
|
0.63
|
0.19
|
0.14
|
−1.73a
|
−2.18a
|
−0.44
|
Asn
|
16.66
|
3.07
|
1.29
|
−2.44a
|
−3.69a
|
−1.25a
|
Sugars and polyols
|
Fru
|
860.33
|
684.72
|
237.87
|
−0.33
|
−1.85a
|
−1.53a
|
Suc
|
96.20
|
180.38
|
104.07
|
0.91
|
0.11
|
−0.79
|
Tal
|
119.04
|
85.27
|
26.98
|
−0.48
|
−2.14a
|
−1.66a
|
Kes
|
60.63
|
84.66
|
24.67
|
0.48
|
−1.30a
|
−1.78a
|
Hep
|
0.80
|
0.29
|
0.18
|
−1.47a
|
−2.19a
|
−0.72
|
mIno
|
11.07
|
24.44
|
4.62
|
1.14a
|
−1.26a
|
−2.40a
|
Sor
|
9.78
|
3.13
|
3.42
|
−1.65a
|
−1.52a
|
0.13
|
Rib
|
9.02
|
5.24
|
1.56
|
−0.78
|
−2.53a
|
−1.75a
|
Gala
|
0.85
|
3.22
|
0.84
|
1.92a
|
−0.02
|
−1.94a
|
Raf
|
0.39
|
1.01
|
0.10
|
1.39a
|
−1.91a
|
−3.29a
|
- The relative concentration of each metabolite is an average of data from six biological replicates obtained through GC–MS. Fold changes were calculated using the formula log2
(treatment/control)
-
aindicates significance (p < 0.05)