Metabolic pathways | Metabolites | Relative concentration | Fold changes | ||||
---|---|---|---|---|---|---|---|
CK | SS | AS | log2 (SS/CK) | log2 (AS/CK) | log2 (AS/SS) | ||
TCA cycle | Cit | 29.28 | 22.00 | 6.81 | −0.41 | −2.10a | −1.69a |
Aco | 1.25 | 1.02 | 0.88 | −0.30 | −0.51 | −0.21 | |
α-KG | 0.55 | 0.52 | 0.26 | −0.09 | −1.09a | −1.00a | |
Succ | 9.17 | 6.45 | 5.28 | −0.51 | −0.79 | −0.29 | |
Fum | 3.70 | 1.65 | 1.02 | −1.16a | −1.86a | −0.70 | |
Mal | 19.01 | 8.10 | 5.86 | −1.23a | −1.70a | −0.47 | |
Glycolysis | Glc | 5.66 | 71.66 | 9.08 | 3.66a | 0.68 | −2.98a |
G6P | 0.56 | 1.29 | 0.27 | 1.19a | −1.06a | −2.25a | |
F6P | 0.54 | 1.32 | 0.23 | 1.30a | −1.24a | −2.54a | |
3-PGA | 0.35 | 0.92 | 0.31 | 1.38a | −0.18 | −1.56a | |
Pyr | 0.68 | 0.63 | 0.57 | −0.10 | −0.25 | −0.15 | |
PEP | 0.15 | 0.62 | 0.07 | 2.05a | −1.15a | −3.19a | |
Amino acids | Glu | 270.41 | 220.74 | 103.83 | −0.29 | −1.38a | −1.09a |
GABA | 101.70 | 85.20 | 42.42 | −0.26 | −1.26a | −1.01a | |
Ala | 67.72 | 69.28 | 24.26 | 0.03 | −1.48a | −1.51a | |
Asp | 51.33 | 32.36 | 11.90 | −0.67 | −2.11a | −1.44a | |
Gly | 21.96 | 13.17 | 4.47 | −0.74 | −2.30a | −1.56a | |
Thr | 9.54 | 7.76 | 7.12 | −0.30 | −0.42 | −0.12 | |
Ser | 8.58 | 9.42 | 2.56 | 0.13 | −1.74 | −1.88 | |
Val | 2.92 | 5.79 | 2.90 | 0.99a | −0.01 | −1.00a | |
Pro | 0.39 | 1.31 | 1.29 | 1.73a | 1.72a | −0.02 | |
Phe | 0.51 | 0.42 | 0.24 | −0.29 | −1.10a | −0.82 | |
Gln | 0.60 | 0.37 | 0.09 | −0.68 | −2.72a | −2.04a | |
Ile | 0.42 | 2.89 | 0.48 | 2.77a | 0.19 | −2.58a | |
Leu | 0.07 | 0.42 | 0.03 | 2.66a | −1.02a | −3.68a | |
Asn | 0.06 | 0.05 | 0.03 | −0.17 | −1.12a | −0.96 | |
Sugars and polyols | Fru | 162.82 | 327.02 | 224.24 | 1.01a | 0.46 | −0.54 |
Suc | 0.54 | 0.92 | 1.72 | 0.76 | 1.67a | 0.90a | |
Tal | 29.78 | 25.25 | 22.97 | −0.24 | −0.37 | −0.14 | |
Kes | 0.29 | 0.40 | 0.33 | 0.45 | 0.19 | −0.26 | |
Hep | 0.56 | 0.36 | 0.85 | −0.64 | 0.60 | 1.24a | |
mIno | 20.79 | 18.76 | 15.98 | −0.15 | −0.38 | −0.23 | |
Sor | 0.52 | 0.39 | 2.35 | −0.42 | 2.16a | 2.58a | |
Rib | 30.99 | 19.85 | 14.86 | −0.64 | −1.06a | −0.42 | |
Gala | 23.45 | 18.76 | 16.26 | −0.32 | −0.53 | −0.21 | |
Raf | 14.24 | 13.45 | 4.35 | −0.08 | −1.71a | −1.63a |