Figure 9

Identification of methylation at Lysine 79 of histone H3. A. MALDI-TOF mass spectrum showing non- (m/z 1335.66), mono- (m/z 1349.68), and di- (m/z 1363.69) methylation at Lysine 79 of histone H3. B. MS/MS spectrum of the peptide precursor ion with the mass 1349.68, demonstrating mono-methylation at Lysine 79 in the peptide ⁷³EIAQDFK⁷⁹TDLR⁸³. However, our data did not indicate that whether histone H3 Lysine 79 methylation was located in certain histone H3 variant.