Figure 1

Consensus sequence and secondary structure prediction of NLPs. Consensus of all 27 type I NLPs (upper line) and 15 type II NLPs (lower line). Residues present in more than 85% of all sequences are in boldface and capitalized, residues present in more than 70% are in boldface and other residues are in more than 50% of all sequences. Cylinders represent α-helices and arrows β-strands. The 2d-structure predictions shown have a level of confidence greater than 33%. White cylinders and arrows represent low confidence level 2d-structures. Asterisks denote invariant residues (100% conserved) in type I NLPs with experimentally verified necrotic activity.