Figure 1

A structural model of NCX1. The schematic illustration is based on the experimental observations and resulting structural model of mammalian NCX1 transporters described in [33–35]. The rectangles and lines represent the TMSs and loops, respectively, of NCX1. The “in” and “out” positions correspond to the cytosol and extracellular space, respectively. See text for details about the RE-loop (reentrant loop), α1, α2, XIP, and CBD regions.