Figure 2
From: Degradation of lipoxygenase-derived oxylipins by glyoxysomes from sunflower and cucumber cotyledons
Possible pathways for degradation of 13-HOD-CoA. Three rounds of classical β-oxidation reactions yield 7-hydroxy-12:2-CoA as the last intermediate which still contains the initial hydroxy-diene system. The first round of β-oxidation is exemplarily depicted with all expected intermediates. Note that in absence of NAD+ the conversion of 13-HOD (or LA) stalls at the 3-hydroxy-intermediate (see Figure 3). Intermediates that have been detected by HPLC or ESI-MS/MS are framed.