Model for regulation of SA biosynthesis by WRKY28 and WRKY46. Upon infection with a pathogen expressing flagellin (Flg22) or avirulence genes (RPP2/4 or AVR4), WRKY28 or WRKY46 are rapidly induced. Activation of FLS2 receptor by Flg22 results in activation of a MAPK cascade, which leads to induction of WRKY28 expression, which subsequently activates directly and likely also indirectly via yet unknown transcription factors (?), ICS1 gene expression leading to SA production. Avirulence factors like AVR4 trigger SA production through a pathway involving genes PAD4, EDS1, CPR1/5/6, EDS5 and ICS1. WRKY46 is rapidly synthesized and either directly or indirectly positively regulates PBS3 gene expression, having a positive influence on SA metabolism.