The CRF domain. (A) A model of CRF proteins in which the position of CRF domain relative to AP2 DNA binding domain that it always accompanies is shown, in addition to a C-terminal domain present in some members. (B) CRF domain. The core consensus sequence and alignment of the CRF domain from representative members of over 125 related CRF proteins is shown. (C) TEH region of the CRF domain found preceding a subset of members of the CRF proteins. Alignment of representative members is shown.