Monoterpene indole alkaloid (MIA) biosynthetic pathway showing the common entry to the pathway through the biosynthesis of strictosidine and its subsequent deglucosylation leading to species-specific end-products identified in Catharanthus roseus and Rauvolfia serpentina. The biosynthetic pathways of MIA precursors and the first MIA biosynthetic steps are common to all MIA-producing species (dark grey background). The species-specific MIA chemical diversity is exemplified in C. roseus and R. serpentina (light greys background) where major advances in molecular biology of MIA biosynthesis have been performed. Chemical structures are coloured in red (indolic moieties), in black (monoterpenoid moieties) and in blue (glucose). Cr, C. roseus (yellow); Rs, R. serpentina (green); STR, strictosidine synthase; SGD, strictosidine β-D-glucosidase; RGD, raucaffricine β-D-glucosidase.