Electrostatic profiles of FYVE domains. Four known FYVE domain structures, i.e. PDB:1DVP, PDB:1HYI, PDB:1WFK, PDB:1X4U and fifteen AtFYVE homology models, i.e. class I-V, are included. All FYVE domains are shown in the same orientation with the membrane binding regions facing down. The red and blue meshes represent the -1 kT/e and +1kT/e equipotential contours of the FYVE domains. The numbers in the upper left corner correspond to the AtFYVE classification described earlier (Fig. 2). The numbers in the lower right corner correspond to total charges on each AtFYVE domain model.