Architecture of the substrate binding pocket of TaOMT2. A, The substrate binding pocket with bound tricetin is shown inside the red circle. The residues neighboring the binding site are shown as green spheres; B, The entrance for the substrate, tricetin (red arrow) and the co-substrate, SAM (blue arrow) into the binding pocket. The substrate passes through a tunnel to reach the partly-buried pocket; C, The red parabola indicates SAM/SAH binding site. SAH is shown in yellow color and the residues neighboring the binding site are shown as orange spheres.