Figure 5

Hydropathy plots of representative proteins. A. The hydropathy plots of the proteins presented in Figure 4 were created by the TMpred algorithm [48] and aligned manually. The numbers indicate the positions of the experimentally-determined TMSs of NCX1, except the underlined numbers that refer to the TMSs of NCX_Mj. The dashed lines indicate the positions of the reentrant loops of NCX1. Most of the large central loop of HsNCX1 and CrNCX is not shown, while the full hydropathy plot of NCX_Mj is divided to two parts that are shown in different scales to achieve the best alignment with the other proteins. B. Hydropathy plots of the full HsNCX1 and CrNCX proteins.